A schematic representation of “Injury Imatinib types and reconstruction algorithm” is shown in Figure 2. Experience on intraoperative vascular pedicle damage during axillary lymph-node dissection by general surgeon is reported and an algorithmic approach regarding types of injuries and available options to repair them in attempt to salvage the flap is developed. The knowledge of what to expect and what to do,
may reduce the incidence of flap loss and reconstruction failure, thus saving the patient from the additional stress of a second procedure. Every surgeon must be aware of such complications and of the available surgical strategies, being then adequately skilled in the different techniques of breast reconstruction including Autophagy inhibitor microvascular surgery which was required to re-establish blood flow in our cases. “
“The transjugular portosystemic shunt, widely used to treat portal hypertension today, may increase the risk of encephalopathy
and reduce effective hepatic flow. To address these issues, a strategy to produce a portocaval shunt (PCS) with hepatic function using intestinal grafts was conceived, and rat models were developed. We transplanted ileal grafts from wild-type and luciferase transgenic Lewis rats to wild-type Lewis rats, anastomosing the graft mesenteric artery (SMA) and portal vein (PV) to the recipient PV trunk and inferior vena cava, respectively. Recipient survival was significantly longer in the partial PCS model, Thiamet G in which the graft SMA was anastomosed to the recipient PV trunk in an end-to-side fashion, than in the total PCS model, with the end-to-end anastomosis. In the partial PCS model, histological and luminescence analyses showed graft survival for 1 month. These results suggest that intestinal grafts can be maintained in the particular conditions required for our strategy. © 2010 Wiley-Liss, Inc. Microsurgery,
“The aim of this study was to evaluate long-term regenerative capacity over a 15-mm nerve gap of an autologous nerve conduit, the biogenic conduit (BC), 16 weeks after sciatic nerve transection in the rat. A 19-mm long polyvinyl chloride (PVC) tube was implanted parallely to the sciatic nerve. After implantation, a connective tissue cover developed around the PVC-tube, the so-called BC. After removal of the PVC-tube the BCs filled with fibrin (n = 8) were compared to autologous nerve grafts (n = 8). Sciatic functional index (SFI) was evaluated every 4 weeks, histological evaluation was performed at 16 weeks postimplantation. Regenerating axons were visualized by retrograde labelling. SFI revealed no significant differences.