The inclusion criteria for the study are as follows: untreated pa

The inclusion criteria for the study are as follows: untreated patients with histologically confirmed invasive breast cancer with one or more measurable metastatic lesions diagnosed by radiological examination. All patients receive primary systemic therapy according to the estrogen receptor and human epidermal growth factor receptor type-2 status of the primary Selleckchem SB203580 breast cancer after the first

registration. After 3 months, the patients without disease progression are randomized to the primary tumour resection plus systemic therapy arm or the systemic therapy alone arm. The primary endpoint is the overall survival, and the secondary endpoints are proportion of patients without tumour progression at the metastatic sites, yearly local recurrence-free survival, proportion of local ulcer/local bleeding, yearly primary tumour resection-free survival, adverse events of chemotherapy, operative morbidity

and serious adverse events. The patient recruitment was commenced in May 2011. Enrolment of 410 patients for randomization is planned over a 5 year recruitment period. We hereby report CCI-779 cell line the details of the study.”
“Mouse Monoclonal antibodies against human adiponectin were produced by the routine method and the specificity of antibodies was verified. These monoclonal antibodies (MoAbs) interacted with the monomeric and trimeric forms of recombinant adiponectin according to the results of a Western blot analysis. Human blood serum was fractionated by gel filtration, and the protein of these fractions was stained using labeled MoAbs. It was established that a single high-molecular-weight

form (HMW) of endogenous adiponectin was detected by this method. The use of competitive enzymelinked immunoassay on the basis of the obtained MoAbs allowed us to show that the sera of healthy male donors contains lower adiponectin concentrations than that of female donors (8.42 +/- 1.59 mu g/ml vs. 11.01 +/- 2.58 mu g/ml, p = 0.01). We also detected statistically significant lower adiponectin levels in the serum of patients with coronary artery disease for both men (6.01 +/- 2.73 mu g/ml vs. 8.42 +/- 1.59 mu g/ml, p = 0.015) and women (5.79 +/- 2.98 mu g/ml vs. 11.01 +/- 2.58 Alvocidib ic50 mu g/ml, p = 0.0003). Therefore, the developed methods for the analysis of the HMW form of adiponectin can be helpful in the diagnostics of the possible implications and assessment of unfavorable prognoses in patients with cardiovascular disorders.”
“Background Adult height has been hypothesized to be inversely associated with coronary heart disease; however, studies have produced conflicting results. We sought to examine the relationship between adult height and the prevalence of coronary artery calcium (CAC), a direct measure of subclinical atherosclerosis and surrogate marker of coronary heart disease.

Subsequent colocalization

analysis defined the YFP-positi

Subsequent colocalization

analysis defined the YFP-positive cells as a subset of the neutrophil population. Using real-time confocal imaging we demonstrate that these cells migrate to sites of inflammation and are involved in innate immune responses towards infections, including Mycobacterium marinum-induced granuloma GW4869 in vivo formation. (C) 2007 Elsevier Ltd. All rights reserved.”
“Although the tumor Suppressor protein p53 is important in the control of various cellular activities, the analysis of p53 in the porcine model has been hampered by a lack of a suitable antibody that is specific for porcine p53. Using a recombinant porcine p53, we generated a rabbit polyclonal antibody (designated SH0797) that is directed against porcine p53. The results of the study show that the antibody is capable of

detecting recombinant p53 protein expressed in Escherichia coli, as well as FLAG-tagged p53 that is expressed ill ill, transfected cells, This demonstrates that the antibody is specific for the porcine p53 protein. The antibody also showed the ability to immunoprecipitate Caspase-independent apoptosis p53 protein from extracts of porcine cells and to cross-react with human p53 protein. In addition, expression of porcine p53 could be induced readily in porcine cells and detected using this new tool. I-his antibody is a useful tool for Use in studies of the cellular pathways that involve p53 in the porcine model. (C) 2008 Elsevier Inc. All rights reserved.”
“Stress granules (SGs) are cytoplasmic foci that rapidly form when cells are exposed to stress. They transiently store mRNAs encoding house-keeping

proteins and allow the selective translation of stress-response proteins (e.g. heat shock proteins). Besides mRNA, SGs contain RNA-binding proteins, such as T cell internal antigen-1 and poly(A)-binding protein 1, which can serve as characteristic SG marker proteins. Recently, some of these SG marker proteins were found to label pathological TAR DNA binding protein of 43kDa (TDP-43)- or fused in sarcoma (FUS)-positive cytoplasmic inclusions in patients with amyotrophic lateral sclerosis BX-795 purchase and frontotemporal lobar degeneration. In addition, protein aggregates in other neurodegenerative diseases (e.g. tau inclusions in Alzheimer’s disease) show a co-localization with T cell internal antigen-1 as well. Moreover, several RNA-binding proteins that are commonly found in SGs have been genetically linked to neurodegeneration. This suggests that SGs might play an important role in the pathogenesis of these proteinopathies, either by acting as a seed for pathological inclusions, by mediating translational repression or by trapping essential RNA-binding proteins, or by a combination of these mechanisms.

Furthermore, ambuic acid also inhibited the biosynthesis of the c

Furthermore, ambuic acid also inhibited the biosynthesis of the cyclic peptide quormones of Staphylococcus aureus and Listeria innocua. These results suggest the potential use of ambuic acid as a lead compound of antipathogenic drugs that target the quorum-sensing-mediated virulence

expression of gram-positive bacteria.”
“Aspergillus niger NCIM 563 produces dissimilar phytase isozymes under solid state and submerged fermentation conditions. Biochemical characterization and applications of Silmitasertib mouse phytase Phy III and Phy IV in SSF and their comparison with submerged fermentation Phy I and Phy III were studied. SSF phytases have a higher metabolic potential as compared to SmF. Phy I is tetramer and Phy II, III and IV are monomers. Phy I and IV have pH optima of 2.5 and Phy II and III have pH optima of 5.0 and 5.6, respectively. Phy I, III and IV exhibited very broad substrate specificity while Phy II was more specific for sodium phytate. SSF phytase is less thermostable as compared to SmF phytase. Phy land II show homology with other known phytases while Phy III and IV show no homology with SmF phytases and any other known phytases from the literature suggesting their unique nature. This is the first report about differences among phytase produced under SSF and SmF by A. niger and this study provides basis for explanation of the stability Natural Product Library cell line and catalytic

differences observed for these enzymes. Exclusive biochemical characteristics and multilevel application of

SSF native phytases determine their efficacy and is exceptional. (C) 2013 Elsevier Ltd. All rights reserved.”
“Background: Potato is the world’s third most important food crop, yet cultivar improvement and genomic research in general remain difficult because of the heterozygous and tetraploid nature of its genome. The development of physical map resources that can facilitate genomic analyses in potato has so far been very limited. Here we present the methods of construction and the general statistics of the first two genome-wide BAC physical maps of potato, which were made from the heterozygous diploid clone RH89-039-16 (RH).\n\nResults: First, a gel electrophoresis-based physical map was made FDA approved Drug Library by AFLP fingerprinting of 64478 BAC clones, which were aligned into 4150 contigs with an estimated total length of 1361 Mb. Screening of BAC pools, followed by the KeyMaps in silico anchoring procedure, identified 1725 AFLP markers in the physical map, and 1252 BAC contigs were anchored the ultradense potato genetic map. A second, sequence-tag-based physical map was constructed from 65919 whole genome profiling (WGP) BAC fingerprints and these were aligned into 3601 BAC contigs spanning 1396 Mb. The 39733 BAC clones that overlap between both physical maps provided anchors to 1127 contigs in the WGP physical map, and reduced the number of contigs to around 2800 in each map separately. Both physical maps were 1.

A , Havana, Cuba), Euvax-B(R) (LG Chemical Ltd , Seoul, Korea), H

A., Havana, Cuba), Euvax-B(R) (LG Chemical Ltd., Seoul, Korea), Hepavax-Gene(R) (Greencross Vaccine Corp., Seoul, Korea) and Engerix-B(R) (GlaxoSmithKline Biologicals, Rixensart, Belgium). Vaccines were administered intramuscularly to healthy adults in three 20 mu g doses at monthly intervals (0-1-2 mo). Four hundred volunteers aged 18 to 45 y (average age, 35 y) non-reactive for serological markers of hepatitis B virus infection were vaccinated. Volunteers were randomly assigned (ratio 1: 1: 1: 1) to one of the four treatment groups. The antibody response (anti-HBs) was assessed at days 60, 90 and 365 post-vaccination using a commercial

AZD1480 nmr kit. The four vaccines showed to be safe and highly immunogenic. Similar seroprotection rates (anti-HBs >= 10 IU/L) about one month after application of the second and third

dose were obtained for Engerix-B(R), Hepavax-Gene(R), Euvax-B(R) and Heberbiovac-HB(R) vaccines 96.7%, 96.6%, 100%, 100% and 98.8%, 89.5%, 100%, 100%, respectively. Heberbiovac-HB(R) vaccine achieved significantly higher geometric mean antibody titers (GMT) and rate of good and hyper-responders at all time-points post-vaccination. The GMT on day 365 after full vaccination was significantly reduced in all groups compared with day 90, although Heberbiovac-HB(R) showed the highest anti-HBs GMT and good-responders rate. The four vaccines were well tolerated and poorly reactogenic. No ACY-241 serious adverse events were observed. This study confirms an overall good immune response and rapid priming for the four vaccines in the course of an accelerated schedule, with higher anti-HBs geometric mean concentrations and better responses for Heberbiovac-HB(R). [WHO primary

Registry Number: RPCEC00000075].”
“Many species of entomophagous arthropods have been introduced either intentionally (through the practice of biological control) or unintentionally to new regions. We examine interactions of these aliens with their new environments in the context of rapid global change linked to human activity. We consider effects of such interactions on establishment and spread of the alien species and effects on indigenous biota and ecosystems. Major elements of global change that affect alien-environment Poziotinib in vivo interactions include landscape modifications by humans (e.g., cultivation, habitat loss and fragmentation) and increases in atmospheric CO(2) and other gases resulting in climate change and other effects (e.g., changes in food quality for herbivores that affect higher trophic levels as well). Alien arthropod predators can alter landscapes for their benefit, to the detriment of indigenous species. A brief review also of blood-feeding alien arthropods makes clear that interactions with the environment critically influence invasions of zoophagous arthropods in general.

Also been observed difference between the second and third sets w

Also been observed difference between the second and third sets with RI45 ”, and in the third set, the RI45 ” present greater values when compared to RI90 ”. Similarly, the HR present difference between the first and all other

sets in all RI. The RI45 ” and RI60 ” showed differences between the second and third sets. However, the DP has demonstrated difference between the first and all others sets in all RI, and, the RI45 ” and RI60 ” showed difference between the second and third sets. Conclusion: According to the Glutaminase inhibitor results, it is concluded that the SBP and HR is sensitive to the number of sets intra-sets, but there was no difference when comparing the RI with each other. However, there is a greater tendency of RI45 ” cause increased cardiac overload, primarily by increased in SBP.”
“Megaherbivores have been lost from most ecosystems world-wide, and current increases in poaching of rhino and elephant spp. threaten their status in the systems where they still occur. Although megaherbivores are said to be key drivers of ecosystem structure and functioning, empirical evidence is strongly biased to studies on African elephant. We urgently need a better understanding of the impact of other megaherbivore species to predict the consequences of megaherbivore

loss.\n\nWe used a unique ‘recolonization experiment’ to test how a megagrazer, white rhinoceros, is affecting the structure of savanna VX-689 Cell Cycle inhibitor grasslands in Kruger National Park (KNP).\n\nWith a 30-year

record of rhinoceros distribution, we quantified how they recolonized KNP following their re-introduction. This allowed us to identify landscapes with high rhino densities and long time since recolonization versus landscapes with low rhino densities that were recolonized more recently but were otherwise biophysically similar. We recorded grassland heterogeneity on 40transects covering a total of 30km distributed across both landscapes. We used two proxies of grassland heterogeneity: % short grass cover and number of grazing lawn patches. Grazing lawns selleck compound are patches with specific communities of prostrate-growing stoloniferous short grass species.\n\nShort grass cover was clearly higher in the high rhino impact (17.5%) than low rhino impact landscape (10.7%). Moreover, we encountered ~20 times more grazing lawns in the high rhino impact landscape. The effect of rhino on number of lawns and on short grass cover was similar to the two dominant geologies in KNP, basalt-derived versus granite-derived soils.\n\nSynthesis. We provide empirical evidence that white rhinoceros may have started to change the structure and composition of KNP’s savanna grasslands. It remains to be tested if these changes lead to other ecological cascading effects. However, our results highlight that the current rhino poaching crisis may not only affect the species, but also threaten the potential key role of this megaherbivore as a driver of savanna functioning.

3 L/min, provided

3 L/min, provided LY2090314 datasheet that precautions are taken to coat collection plates to minimize bounce and entrainment.”
“PURPOSE. To report four cases of zoonotic ophthalmodirofilariasis infection caused by Dirofilaria repens in Hungary.\n\nMETHODS. Four cases of ophthalmofilariasis have been treated at our department during the last 14 months. A subconjunctival moving worm was observed by slit lamp biomicroscopy in two cases. In one of these a living filaria was surgically removed, but the other disappeared. Red eye and migrating edema were the presenting signs in two cases. A biopsy taken from

the subcutaneous masses disclosed D repens.\n\nRESULTS. Histopathologic or parasitologic examination identified a female D repens in every case. Laboratory alterations were not found. Symptoms

subsided after treatment.\n\nCONCLUSIONS. The clinical presentation of filariasis is not always straightforward, and a high index of suspicion is necessary in cases presenting with orbital or periorbital inflammation. During the past 10 years the identification of locally acquired infections by D repens has increased in Hungary. (Eur J Ophthalmol 2009; 19: 675-8)”
“Background: Stress echocardiography is an established technique for diagnosis, risk stratification, and prognosis in patients with see more known or suspected coronary artery disease. The ability of stress echocardiography to predict clinical outcomes, such as coronary angiography and revascularization, has not been reported previously. The purpose of this study was to evaluate the clinical outcomes of coronary angiography, revascularization, and cardiac events in patients undergoing stress echocardiography.\n\nMethods: A total of 3121 patients (mean age, 60 +/- 13 years; 48% men) undergoing stress echocardiography HKI-272 (41% treadmill, 59% dobutamine) were assessed. Follow-up (mean, 2.8 +/- 1.1 years) for subsequent coronary angiography, revascularization

(percutaneous coronary intervention [PCI] or coronary artery bypass grafting [CABG]), and confirmed hard events (nonfatal myocardial infarction or cardiac death) was obtained.\n\nResults: Stress echocardiographic results were normal (peak wall motion score index [pWMSI], 1.0) in 66% and abnormal (pWMSI > 1.0) in 34% of patients. The pWMSI effectively risk-stratified patients into low-risk (pWMSI, 1.0; 0.8% per year), intermediate-risk (pWMSI, 1.1-1.7; 2.6% per year), and high-risk (pWMSI > 1.7; 5.5% per year) groups for future cardiac events (P < .0001). Early coronary angiography (30 days following stress echocardiography) was performed in only 35 patients (1.7%) with normal stress echocardiographic results and 267 patients (25.5%) with abnormal stress echocardiographic results (P < .0001). Late coronary revascularization (2 years following stress echocardiography) occurred in 80 patients (PCI, 2.

Surface plasmon resonance assays revealed that O-sulfated K5 with

Surface plasmon resonance assays revealed that O-sulfated K5 with a high degree of sulfation [K5-OS(H)] and N,O-sulfated K5 with a high [K5-N,OS(H)] or low [K5-N,OS(L)] sulfation degree, but not unmodified

K5, N-sulfated K5, and O-sulfated K5 with low levels of sulfation, prevented the interaction between HPV-16 pseudovirions and immobilized heparin. In cell-based assays, K5-OS(H), K5-N,OS(H), and K5-N,OS(L) inhibited HPV-16, HPV-18, and HPV-6 pseudovirion infection. Their 50% inhibitory concentration was between 0.1 and 0.9 mu g/ml, without evidence of cytotoxicity. These findings provide insights into the design of novel, safe, and broad-spectrum microbicides against genital

HPV infections.”
“This study investigates the applicability of D-PAM, the inverso form of the Protein A Mimetic GKT137831 manufacturer synthetic peptide affinity ligand (PAM) obtained from the screening of a multimeric combinatorial peptide library, in monoclonal IgG isolation from ascitic fluids and cellular supernatants. D-PAM PCI-34051 cost affinity columns, prepared by immobilizing the all-D peptide on the commercially available support Emphaze (TM), were able to capture monoclonal antibodies in a single chromatographic step, with a recovery yield and purity degree above 90% and full recovery of antibody activity.\n\nD-PAM/Emphaze resin showed a host cell protein (HCP) and DNA reduction similar to protein A sorbent. Indeed, LY2835219 ic50 column capacity, determined by applying a large excess of purified antibodies to 1 mL of column bed volume, was always higher than 50 mg/mL.\n\nD-PAM/IgG interaction was characterized by isothermal titration calorimetry (ITC) and an analysis of binding isotherms, obtained for titration of ST2146, ST1485 and 7H3 IgG monoclonal antibodies, suggested that two peptides bind simultaneously to the

IgG molecule, with a K-A (equilibrium association constant) of 3.4, 6.2 and 3.4 x 10(4) M-1, and a Delta H (change in enthalpy) of -1.3, -4.2 and -4.1 kcal mol(-1), respectively. (C) 2008 Elsevier B.V. All rights reserved.”
“Lung cancer is the major health problem and leading cause of cancer-related deaths worldwide owing to late diagnosis and poor prognosis. Aberrant promoter methylation is an important mechanism for silencing tumor-suppressor genes in cancer and a promising tool for the development of molecular biomarkers. Ras association domain family IA (RASSF1A), a pivotal gatekeeper of cell cycle progression, is highly methylated in a wide range of human sporadic tumors, including lung cancer. However, no significant prognostic implications have been observed in most studies qualitatively analyzer by methylation-specific PCR (MSP). We found that the RASSF1A promoter was aberrantly methylated in 44.

Gliovac administration in patients that have failed standard of c

Gliovac administration in patients that have failed standard of care therapies showed minimal toxicity and enhanced overall survival (OS). Six-month

(26 weeks) survival for the nine Gliovac patients was 100% versus 33% in control group. At week 40, the published overall survival was 10% if recurrent, reoperated patients were not treated. In the Gliovac treated group, the survival at 40 weeks was 77%. Our data suggest that Gliovac has low toxicity and a promising ubiquitin-Proteasome system efficacy. A phase II trial has recently been initiated in recurrent, bevacizumab naive GBM patients (NCT01903330). (c) 2015 The Authors. Published by Elsevier Ltd.”
“Transcatheter aortic valve implantation (TAVI) has become a feasible therapeutic option for the management of high-risk patients with severe degenerative aortic stenosis. Recently it has been extended to high-risk patients with severe aortic regurgitation. Degenerative aortic valve disease is generally uncommon in heart transplant recipients. We report the case of a 75-year-old man in whom severe degenerative aortic regurgitation developed 14 years after heart transplantation (HTx). Because of multiple comorbidities and high surgical risk, TAVI was preferred. A 29-mm CoreValve prosthesis

(Medtronic Inc, Minneapolis, MN) was successfully implanted using a transfemoral approach. (C) 2013 by The Society of Thoracic Surgeons”
“Purpose: We prospectively examined the extent Selleckchem Go6983 and timing of testosterone recovery in patients with prostate cancer

treated with 2 years of androgen suppression.\n\nMaterials and Methods: A total of 153 patients with pT3N0M0 prostate cancer or positive margins after radical prostatectomy, or with prostate specific antigen relapse were treated with radiation to the prostate bed plus 2 years of androgen suppression as per a phase II study. Androgen suppression consisted of nilutamide for 4 weeks plus busereline acetate bimonthly for 2 years. Serum testosterone was measured at baseline, every 4 months during androgen suppression and every 6 months after androgen suppression during followup. Testosterone recovery to supracastrate levels, and to baseline and/or normal levels was estimated using Kaplan-Meier methods. Prognostic factors for testosterone recovery were examined.\n\nResults: A total of 121 patients Selleck Pevonedistat who completed 2 years of androgen suppression and 20 patients who received shorter durations of androgen suppression (median 16 months) were available for testosterone recovery analysis. Median followup after finishing androgen suppression was 38.9 months. All patients achieved castrate levels on androgen suppression. At 36 months after completion of androgen suppression 93.2% and 71.5% had recovery to supracastrate (median time 12.7 months), and to baseline and/or normal testosterone levels (median time 22.3 months), respectively. On multivariate analysis younger age (younger than 60 years, p = 0.

Another goal was to determine the influence of 2 different

Another goal was to determine the influence of 2 different Smoothened Agonist clinical trial regimens for dressing changes on rates of catheter-related bloodstream infections and costs.\n\nMethods A convenience sample and an exploratory design were used to collect data in 2 phases, including 30 days to establish baseline information and 30 days each during which patients received dressing care for a central venous catheter with a transparent dressing alone and with a transparent dressing plus a chlorhexidine-impregnated dressing. Nurses also participated in a survey of knowledge about infection control practices related to central

catheters.\n\nResults Few differences were found between the transparent dressing alone and a chlorhexidine-impregnated dressing plus the transparent dressing. A serendipitous finding was the number of times that central catheters were accessed daily.\n\nConclusions The results of this project suggest that infection control efforts may be most appropriately focused on processes rather than on products. (American Journal of Critical Care. 2009; 18: 514-521)”
“The selleck chemicals llc release of cytokines by T cells strongly defines their functional activity in vivo. The ability to produce multiple cytokines has been associated with beneficial immune responses in cancer and infectious

diseases, while their progressive loss is associated with T-cell exhaustion, senescence and anergy. Consequently, strategies that enhance the multifunctional status of T cells are a key for immunotherapy. Dendritic cells (DCs) are professional antigen presenting cells that regulate T-cell functions by providing positive and negative co-stimulatory signals. A key negative regulator of T-cell activity is provided by binding of programmed death-1 (PD-1) receptor on activated T cells, to its ligand PD-L1, expressed

this website on DCs. We investigated the impact of interfering with PD-L1/PD-1 co-stimulation on the multifunctionality of T cells, by expression of the soluble extracellular part of PD-1 (sPD-1) or PD-L1 (sPD-L1) in human monocyte-derived DCs during antigen presentation. Expression, secretion and binding of these soluble molecules after mRNA electroporation were demonstrated. Modification of DCs with sPD-1 or sPD-L1 mRNA resulted in increased levels of the co-stimulatory molecule CD80 and a distinct cytokine profile, characterized by the secretion of IL-10 and TNF-alpha, respectively. Co-expression in DCs of sPD-1 and sPD-L1 with influenza virus nuclear protein 1 (Flu NP1) stimulated Flu NP1 memory T cells, with a significantly higher number of multifunctional T cells and increased cytokine secretion, while it did not induce regulatory T cells. These data provide a rationale for the inclusion of interfering sPD-1 or sPD-L1 in DC-based immunotherapeutic strategies.

The amplitude and the Vmax of the anterior LV epicardial MAP incr

The amplitude and the Vmax of the anterior LV epicardial MAP increased obviously, and the APD prolonged mainly in late and final VS-6063 in vitro phase of repolarization.”
“In this research, an improved method for preparation of optically pure beta-hydroxy-alpha-amino acids, catalyzed by serine hydroxymethyl transferase with threonine aldolase activity, is reported. Using recombinant serine hydroxymethyl transferase (SHMT), an enzymatic resolution

process was established. A series of new substrates, beta-phenylserine, beta-(nitrophenyl) serine and beta-(methylsulfonylphenyl) serine were used in the resolution process catalyzed by immobilized Escherichia coli cells with SHMT activity. It was observed that the K (m) for l-threonine was 28-fold higher than that for l-allo-threonine, suggesting that this enzyme can be classified as a low-specificity l-allo-threonine aldolase. The results also shows that SHMT activity with beta-phenylserine

as substrate was about 1.48-fold and 1.25-fold higher than that with beta-(methylsulfonylphenyl) MK-0518 supplier serine and beta-(nitrophenyl) serine as substrate, respectively. Reaction conditions were optimized by using 200 mmol/l beta-hydroxy-alpha-amino acid, and 0.1 g/ml of immobilized SHMT cells at pH 7.5 and 45A degrees C. Under these conditions, the immobilized cells were continuously used 10 times, yielding an average conversion Selleckchem Bindarit rate of 60.4%. Bead activity did not change significantly the first five times they were used, and the average conversion rate during the first five instances was 84.1%. The immobilized cells exhibited favourable operational stability.”
“Objectives. We sought to study suicidal behavior prevalence and its association with social and gender disadvantage, sex work, and health factors among female sex workers in Goa, India.\n\nMethods. Using respondent-driven sampling, we recruited 326 sex workers in Goa for an interviewer-administered questionnaire regarding self-harming behaviors, sociodemographics, sex work, gender disadvantage, and health. Participants were tested for sexually transmitted

infections. We used multivariate analysis to define suicide attempt determinants.\n\nResults. Nineteen percent of sex workers in the sample reported attempted suicide in the past 3 months. Attempts were independently associated with intimate partner violence (adjusted odds ratio [AOR]=2.70; 95% confidence interval [CI]=1.38, 5.28), violence from others (AOR=2.26; 95% CI=1.15, 4.45), entrapment (AOR=2.76; 95% CI=1.11, 6.83), regular customers (AOR=3.20; 95% CI=1.61, 6.35), and worsening mental health (AOR=1.05; 95% CI=1.01, 1.11). Lower suicide attempt likelihood was associated with Kannad ethnicity, HIV prevention services, and having a child.\n\nConclusions. Suicidal behaviors among sex workers were common and associated with gender disadvantage and poor mental health.