The bloodletting therapy or iron chelation therapy used before selleckchem cirrhosis or diabetes can significantly improved the prognosis of the hemochromatosis patients. When
the patient with the following symptoms: Fatigue, right upper quadrant pain, joint pain, cartilage calcinosis disease, impotence, reduced libido, and heart failure or diabetes, whose diagnosis is not clear, detection of serum iron, transferrin saturation and ferritin is needed. Patients with abnormal detection results can underwent liver MRI, liver biopsy or the genetic testing of C28Y and H63D in order to diagnose the hemochromatosis learn more and be treated as early as possible. Key Word(s): 1. Hemochromatosis; 2. Clinical analysis; Presenting Author: HERYDJAGAT PURNOMO Additional Authors: HIRLAN HIRLAN, KASNO KASNO, EDI SUDIJANTO, DARMONO DARMONO, DALDIYONO DALDIYONO,
R. DJOKOMOELJANTO, SULTANAMH FARADZ Corresponding Author: HERYDJAGAT PURNOMO Affiliations: Dr Kariadi Hospital Diponegoro University, Disvison of gastroenterohepatology; Dr CiptoMangunkusumo; CEBIOR Diponegoro University Objective: NAFLD is considered as hepatic manifestation of metabolic syndrome (MS). Insulin resistance is a key component of metabolic syndrome. The aim of study was to determine correlation between severity of MS and histology of NAFLD. Methods: A total of 155 subjects (80 NAFLD cases and 75 healthy controls) were included. Liver biopsy was performed in all NAFLD cases. NAFLD severity was determined according to NAFLD Activity Score (NAS). NAFLD spectrum score was 1 to 5. Subject with NASH was grade as 5 and who without central obesity in control group was grade as 1. MS was defined by International Diabetes Federation criteria. medchemexpress Insulin resistance was assessed by the Homeostatic model Assessment-Insulin
Resistance (HOMA-IR) index. Results: The average of age was 44,9 ± 10,20 years, 85 (54.8%) male. Liver biopsies yield 29 non-alcoholic steatohepatisis (NASH), 40 possible NASH and 11 subjects were simple steatosis. In the cases group subjects had 4 components of MS 42%, 3 component 40% and 5 component 17%. Severity of Metabolic syndrome had a strong correlation with NAFLD spectrum score (r = 0.8; p < 0,001). The degree of HOMA-IR index had a moderate correlation with NAFLD spectrum score (r = 0,58; p < 0,001) Conclusion: Severity of metabolic syndrome has a strong correlation with histology of NAFLD spectrum score Key Word(s): 1. severity; 2. non alcoholic liver disease; 3. metabolic syndrome; 4.