Figure S3 BMPR-IB inhibited the subcutaneous growth of glioblastoma cells. A) The subcutaneous models of nude glioblastoma cells, which over-expressed of BMPR-IB and knocked down BMPR-IB. B) The tumor masses derived from the subcutaneous
xenograft. C) H&E staining of tumors derived from subcutaneous xenografts of glioblastoma cells. N: Normal connective tissue; T: Glioblastoma tissue. Figure S4 Quantitative check details analysis of CD34 positive microvessels in the glioblastoma specimens. Glioblastoma ABT 737 specimens that were derived from U251-C/U251-IB and SF763-si-Con/SF763-si-IB cells were stained by CD34 using immunohistochemistry method. Error bars represent SD (performed selleck products in triplicate). *p < 0.01. Table S1 Primer sequences for p21, p27, p53, CDK2, CDK4, Skp2, BMPR-IB (human) and GAPDH. (DOC 4 MB) References 1. Maher EA, Furnari FB, Bachoo RM, et al.: Malignant glioma: genetics and biology of a grave matter. Genes Dev 2001, 15:1311–1333.PubMedCrossRef 2. Gonzalez J, de Groot J: Combination therapy for malignant glioma based on PTEN status. Expert Rev Anticancer Ther 2008, 8:1767–1779.PubMedCrossRef 3. Ye F, Gao Q, Cai MJ: Therapeutic targeting of EGFR in malignant gliomas. Expert
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