0 (SD 7.9). Of men with UI at 6 weeks after surgery, 76.7%
in the RP group and 63.2% in the TURP group still had UI at 12 months. Any UI at 12 months was significantly associated with reduced HRQoL in the RP group and lower EQ-5D and SF-12 Mental Component Scores in the TURP group. Conclusion: Any UI is a significant factor in reduced HRQoL in men following prostate surgery, particularly younger men who undergo RP. Its importance to patients as an adverse outcome should not be underestimated. Neurourol. Urodynam. 31: 465-469, 2012. (C) 2012 Wiley Periodicals, Inc.”
“Samples of precipitation events (snow and rain) in Dalian, a typical coastal town in China, were analyzed for perfluorosulfonates (PFSAs) and perfluorocarboxylates GSK923295 (PFCAs) to investigate atmospheric contamination by these compounds. In the snow event on December 16, 2006, samples were collected from 21 different sites and in another 6 precipitation events, samples were collected from a single location. Four PFSAs (C4, C6, C8, C10) and seven PFCAs (C6-12) were analyzed. Among the homologues, perfluorooctane sulfonate (PFOS) concentrations were CH5183284 the highest with a geometric mean (CM) of 145 ng/L (n = 21) during the snow event on December 16, 2006. followed by perfluorooctanoate (PFOA) with
a GM of 24.7 ng/L (n = 21). Concentrations of perfluorobutane sulfonate (PFBS). perfluorohexane sulfonate (PFHxS) and perfluoroheptanoate (PFHpA) were more Pexidartinib concentration than two orders of magnitude lower than that of PFOS. Other PFSAs and PFCAs were found to be below the limit of detection in all the samples. In other 6 precipitation events, PFSAs and PFCAs were detected approximately in the same order of magnitude in both snow and rain. The results indicate that wet deposition may be a potential transport mechanism of perfluorinated chemicals
in the environment. (C) 2009 Elsevier Ltd. All rights reserved.”
“Single-cell functional proteomics assays can connect genomic information to biological function through quantitative and multiplex protein measurements. Tools for single-cell proteomics have developed rapidly over the past 5 years and are providing approaches for directly elucidating phosphoprotein signaling networks in cancer cells or for capturing high-resolution snapshots of immune system function in patients with various disease conditions. We discuss advances in single-cell proteomics platforms, with an emphasis on microchip methods. These methods can provide a direct correlation of morphological, functional and molecular signatures at the single-cell level. We also provide examples of how those platforms are being applied to both fundamental biology and clinical studies, focusing on immune-system monitoring and phosphoprotein signaling networks in cancer.”
“Only 20-30% out of the treated hypertensive patients in Europe are achieving blood pressure (BP) control.