Cells h Her. It is therefore important to evaluate and interpret the pr Clinical activity T ADV in connection with the type of tumor and its microenvironment. In this study MMCM invasive Imatinib MRI was used to study the influence of the microenvironment of h Yourself on tumor angiogenesis and the response to DMXAA. The results demonstrate the usefulness of MRI MMCM to the differences between Vaskul Ren tumors Extrauteringravidit t Orthotopic and provide evidence for early Vaskul Re st Characterize leaders in vivo effects of DMXAA. Orthotopic tumors showed an increase in Vaskul Ren volume compared to ectopic tumors. Although the effect of the implantation site on tumor Vaskul Whose characteristics k Were evaluated may, depending on the model Reported similar results.
Use MMCMMRI Kim et al have shown that the blood volume c tumors Lon orthotopic h Ago as ectopic tumors. Taurine However Zechmann and colleagues have shown that hormones have sensitive experimental orthotopic prostate tumors decreased perfusion is compared against subcutaneous tumors. The first effects of DMXAA in pr Clinical tumor models were observed, z Select Ver changes The Vaskul Ren permeability t leads to extravasation of egg whites, Erh Hte viscosity t, the circulation and circulatory arrest eventual collapse and necrosis . Several studies by us and others reported a potent Vaskul Ren disruptive DMXAA a series of subcutaneous and animal models of human cancers. Recently the anti-tumor activity of DMXAA against chemically induced mammary tumors was examined in rats.
To the best of our knowledge, this is the first study to antivaskul Ren activity DMXAA t with the same type of tumor histology to verify established orthotopic and ectopic sites. The Ansto for the development of their DMXAA F ability, high levels of TNF was induced in situ. In our study, MRI results showed MMCM a differentiated response between tumors and vascular Diseases with ectopic ectopic DMXAA in orthotopic tumors with a gr Eren reducing Vaskul Ren volume, orthotopic tumors. In accordance with this observation, the analysis of TNF treatment 3 hours after Erh Concentrations of TNF increase in ectopic tumors compared to tumors shown orthotopic. The effects of TNF on endothelial integrity t Permeability and t are demonstrated previously.
Using gene knockout TNF / M was nozzles Shown that tumor cells synthesize TNF mRNA and protein after DMXAA treatment. Significant attenuator Monitoring the anti-tumor activity of t after the treatment was observed in tumors of DMXAA in murine c Lon grew 38 in TNF receptor / mice. The same study has also shown that TNF receptor / mice h Here DMXAA than their wild-type counterparts with TNF in Wirtstoxizit t and anti-tumor activity of t tolerated Of DMXAA. Moreover, studies by us and others, the occurrence of endothelial apoptosis as early as 30 minutes have been reported after drug administration schl # adds a direct drug effect on the endothelium. It is now believed that the effects antivaskul Re DMXAA a result of both direct effects on tumor endothelial drugs and indirect effects of cytokines and growth factors. In a recent study, a good correlation between plasma concentrations observed in serum.