In terms of brain structure, pre-SMA and SMA are separable based on their patterns of structural connectivity in both humans and monkeys (Inase et al., 1999 and Johansen-Berg et al., 2004). Furthermore, BIBF 1120 in humans, pre-SMA has been parcellated into anterior and posterior regions based

on differences in functional connectivity (Zhang, Ide, & Chiang-shan, 2012). As the resolution of these techniques improves, further sub-divisions may also be detectable. In the context of the lesion described here, the complexity model predicts that stopping responses could be initiated by structures other than pre-SMA. One possible candidate is adjacent, caudally located SMA, where stimulation or lesions have been found to affect the ability to inhibit actions (Drewe, 1975,

Fried et al., 1991 and Picton et al., 2007), and which has also been associated with automatic, unconscious inhibition of voluntary actions (Sumner et al., 2007). Therefore it might be possible that pre-SMA is not specifically required for stopping, and instead plays a more important role in switching response plans. A challenge to this interpretation comes from recent work where pre-SMA activity was modulated using TMS during performance of a response inhibition task. The authors reported that implementation of the stopping process was disrupted without affecting the ability to update response plans ( Cai et al., 2012 and Obeso et al., 2013). Macrostimulation of pre-SMA in humans has also been found to halt motor responses ( Filevich et al., 2012 and Swann et al., 2012). PI3K inhibitor Although these studies suggest that pre-SMA is directly involved in stopping responses, the use of SMA as a control site could have extended their findings, and the possibility of non-localised effects of the stimulation modalities cannot be entirely discounted, particularly since SMA is

directly adjacent to pre-SMA. However, Acetophenone if stimulation of pre-SMA can inhibit a response but a lesion of the caudal pre-SMA does not affect stopping, how can these apparently inconsistent positions be reconciled? One approach is to consider whether inhibitory control of behaviour might not be governed by a unitary system. In humans, although the Go-NoGo and STOP-signal paradigms have often been grouped collectively under the term ‘response inhibition’, they are actually associated with quantitatively different patterns of activation (Swick, Ashley, & Turken, 2011) – suggesting that ‘not going’ and ‘stopping’ are not necessarily synonymous. Recently it has been proposed that inhibiting a response might be achieved in two different ways: reactive and proactive (Aron, 2011). Reactive inhibition is conceptualised as a global stopping mechanism analogous to the handbrake in a car, whereas proactive inhibition is a selective system deployed when stopping is anticipated, more like a footbrake.