BNC formulations for oral administration. In most Cases, the aim was that the oral bioavailability or DNA-PK Erh Increase the gastrointestinal absorption or bypassing the first-pass metabolism to improve. Various techniques have been adopted for the production of formulation formulations. The following sections present the studies on individual drugs for oral administration via GLS / CLN. S ure Retino Each trans. In a study GLS were responsible Alltrans S Retino acid Than by the method using HPS Compritol 888 ATO as lipid matrix produced ®. The purpose of this study, the oral bioavailability of poorly was l Soluble medicines that improve by SLN. The pharmacokinetic study was conducted in m Nnlichen rats after oral administration of 8 mg kg performed ATRA in various formulations.
It was found that the relative bioavailability of ATRAwas significant h Ago in the case of NLS L Solution ATRA. The amount of surfactant in formulations SLN was also shown a significant effect on the oral absorption of ATRA. The study showed that the absorption of ATRA significantly improved by GLS. Although ATRA absorption in the case of an emulsion formulation was increased, it was very unstable. The apomorphine. Apomorphine is an agonist of the dopamine receptor, the. For treating Parkinson’s disease, s is used However, apomorphine showed poor oral bioavailability due to first-pass effect. Tsai et al. SLN made to improve the oral bioavailability of apomorphine and brain regional distribution of apomorphine.
SLN were prepared using two emulsifiers, glyceryl monostearate and polyethylene glycol monostearate, individually. The study showed a significant effect of emulsifiers on the physicochemical properties of the SLN. Average diameter of SLN using GMS was gr Him as the SLN using PMS. The trapping efficiency SLN was 90%. The SLN using PMS was more stable with regard to particle S encapsulation efficiency and that SLN prepared with GMS, when incubated in simulated intestinal environment. Nevertheless, both apomorphine SLN showed a bioavailability of 12 to 13 times h from Than the apomorphine-L Measurement solutions for the oral administration of formulations SLN and Solutions. In addition, increased Hte be the distribution of drugs in the striatum after administration of SLN. The antiparkinsonian apomorphine was in rats with 6 hydroxydopamine induced L Investigated emissions.
Contralateral rotational behavior suggested the improvement of the condition after the oral administration of apomorphine both loaded SLN. However, SLN prepared with SPM showed a better effect than the SLN prepared with GMS. The study suggests that SLN k Nnte a promising strategy for the oral administration of apomorphine be. Asarone. The SLN asarone were laden prepared by the method of ultrasonic homogenization. This paper examines the potential to improve oral bioavailability of GLS and tissue uptake of asarone. The pharmacokinetic study in m Nnlichen rats at an oral dose equivalent to 10 mg kg Asarone proposed that the relative bioavailability of asarone significantly compared SLN asarone group asarone L Improved solution. In addition, the study showed also an increased uptake of asarone in the brain and lung cancer in the SLN group compared asarone .