Cancer Res 1997, 57: 2384–2387.PubMed 9. Kotani M, Detheux M, AR-13324 in vivo Vandenbogaerde A, Communi D, Vanderwinden JM, Le Poul E, Brezillon S, Tyldesley R, Suarez-Huerta N, Vandeput F, Blanpain C, Schiffmann SN, Vassart G, Parmentier M: The metastasis suppressor gene KiSS-1 encodes kisspeptins, the natural ligands of the orphan G protein-coupled receptor GPR54. J Biol Chem 2001, 276: 34631–34636.CrossRefPubMed 10. Muir AI, Chamberlain L, Elshourbagy NA, Michalovich D, Moore DJ, Calamari A, Szekeres PG, Sarau HM, Chambers JK, Murdock P, Steplewski K, Shabon U, Miller JE, Middleton SE, Darker JG, Larminie CG, Wilson S, Bergsma DJ, Emson P, Faull R, Philpott KL, Harrison DC: AXOR12, a novel human G protein-coupled
receptor, activated by the peptide KiSS-1. J Biol Chem 2001, 276: 28969–28975.CrossRefPubMed 11. Ohtaki T, Shintani Y, Honda S, Matsumoto H, Hori A, Kanehashi K, Terao Y, Kumano S, Takatsu Y, Masuda Y, Ishibashi Y, Watanabe T, Asada M, Yamada T, Suenaga M, Kitada C, Usuki S, Kurokawa T, Onda H, Nishimura O, Fujino M: Metastasis suppressor gene KiSS-1 encodes peptide ligand of a G-protein-coupled receptor. Nature 2001, 411: 613–617.CrossRefPubMed 12. Niida A, Wang Z, Tomita K, Oishi S, Tamamura H, Otaka A, Navenot JM, Broach JR, Peiper SC, Fujii N: Design and synthesis of downsized metastin (45–54) analogs
with maintenance of high GPR54 agonistic activity. Bioorg Med Chem Lett 2006, 16: 134–137.CrossRefPubMed 13. Shirasaki F, Takata M, Hatta N, Takehara K: Loss of expression of the metastasis suppressor gene
KiSS1 during melanoma buy eFT-508 progression and its association with LOH of chromosome 6q16.3-q23. Cancer Res 2001, 61: 7422–7425.PubMed 14. Ringel MD, Hardy E, Bernet VJ, Burch HB, Schuppert F, Burman KD, Saji M: Metastin receptor is overexpressed in papillary thyroid cancer and activates MAP kinase in thyroid cancer cells. J Clin Endocrinol Metab 2002, 87: 2399.CrossRefPubMed 15. Ikeguchi M, selleck chemical Hirooka Y, Kaibara N: Quantitative reverse transcriptase polymerase chain reaction analysis for KiSS-1 and orphan G-protein-coupled receptor (hOT7T175) gene expression in hepatocellular carcinoma. J Cancer Res Clin Oncol 2003, 129: 531–535.CrossRefPubMed 16. Sanchez-Carbayo M, Capodieci P, Cordon-Cardo C: Tumor suppressor role of KiSS-1 in bladder cancer: loss of Buspirone HCl KiSS-1 expression is associated with bladder cancer progression and clinical outcome. Am J Pathol 2003, 162: 609–617.PubMed 17. Dhar DK, Naora H, Kubota H, Maruyama R, Yoshimura H, Tonomoto Y, Tachibana M, Ono T, Otani H, Nagasue N: Downregulation of KiSS-1 expression is responsible for tumor invasion and worse prognosis in gastric carcinoma. Int J Cancer 2004, 111: 868–872.CrossRefPubMed 18. Ikeguchi M, Yamaguchi K, Kaibara N: Clinical significance of the loss of KiSS-1 and orphan G-protein-coupled receptor (hOT7T175) gene expression in esophageal squamous cell carcinoma. Clin Cancer Res 2004, 10: 1379–1383.CrossRefPubMed 19.