Blunt JW, Copp BR, Hu W-P, Munro MHG, Northcote PT, Prinsep MR: Marine natural products. Nat Prod Rep 2008, 25:35–94.CrossRefPubMed 2. Tan LT: Bioactive natural products from marine cyanobacteria for drug discovery. Phytochem 2007, 68:954–979.CrossRef 3. Tidgewell K, Clark BR, Gerwick WH: The natural products chemistry of cyanobacteria. Comprehensive Natural Products Chemistry Pergamon DAPT in vitro Press, in press. 4. Chang Z, Flatt P, Gerwick WH, Nguyen V-A, Willis CL, Sherman DH: The barbamide biosynthetic gene cluster: A novel cyanobacterial system of mixed polyketide synthase (PKS)-non-ribosomal peptide synthetase (NRPS) origin involving an unusual trichloroleucyl

starter unit. Gene 2002, 296:235–247.CrossRefPubMed 5. Chang Z, Sitachitta N, Rossi JV, Roberts MA, Flatt PM, Jia J,

Sherman DH, Gerwick WH: Biosynthetic pathway and gene cluster analysis of curacin A, an antitubulin natural product from the tropical marine cyanobacterium Lyngbya majuscula. J Nat Prod 2004, 67:1356–1367.CrossRefPubMed 6. Edwards DJ, Marquez BL, Nogle LM, McPhail K, Goeger DE, Roberts MA, Gerwick WH: Structure and biosynthesis of the jamaicamides, Protein Tyrosine Kinase inhibitor new mixed polyketide-peptide neurotoxins from the marine cyanobacterium Lyngbya majuscula. Chem Biol 2004, 11:817–833.CrossRefPubMed 7. Gu L, Geders TW, Wang B, Gerwick WH, Håkansson K, Smith JL, Sherman DH: GNAT-like strategy for polyketide chain initiation. Science 2007, 318:970–974.CrossRefPubMed 8. Cragg GM,

Newman DJ, Snader KM: Natural products in drug discovery and development: The United States National Cancer Institute Role. Phytochemicals in Human Health Protection, Nutrition, and Plant Defense (Edited by: Romeo JT). New York: Kluwer Academic/Plenum Publishers 1999, 1–29. 9. Suyama TL, Gerwick WH: Stereospecific total synthesis of somocystinamide A. Org Lett 2008, 10:4449–4452.CrossRefPubMed 10. Pfeifer BA, Wang CCC, Walsh CT, Khosla C: Biosynthesis of yersiniabactin, a complex polyketide-nonribosomal peptide, using Escherichia coli as a heterologous host. Appl Environ Microbiol 2003, 69:6698–6702.CrossRefPubMed 11. Schmidt EW, Nelson JT, Rasko DA, Sudek S, Eisen JA, Haygood MG, Ravel J: Patellamide A and C biosynthesis by a microcin-like pathway in Prochloron didemni , the cyanobacterial symbiont of Lissoclinum patella. Proc Natl Acad Sci enough USA 2005, 102:7315–7320.CrossRefPubMed 12. Watanabe K, Hotta K, Praseuth AP, Koketsu K, Migita A, Boddy CN, Wang CCC, Oguri H, Oikawa H: Total biosynthesis of antitumor nonribosomal peptides in Escherichia coli. Nat Chem Biol 2006, 2:423–428.CrossRefPubMed 13. Wilkinson B, Micklefield J: Mining and engineering natural-product biosynthetic pathways. Nat Chem Biol 2007, 3:379–386.CrossRefPubMed 14. Galm U, Shen B: Expression of biosynthetic gene clusters in heterologous hosts for natural product production and combinatorial biosynthesis. Exp Op Drug Discov 2006, 1:409–437.CrossRef 15.