We characterized the amplitude-dependent SPL of three commercial dextran-iron oxide nanoparticle suspensions through saturation to 94 kA/m with a calorimeter comprising a solenoid coil that generates a uniform field to 100 kA/m at similar to 150 kHz. We also describe a novel method to empirically determine the appropriate range of the heating curve from which the SPL is then calculated. These results agree with SPL values calculated from the phenomenological Box-Lucas equation. We note that the amplitude-dependent SPL among the samples was markedly different, indicating
ACP-196 significant magneto-structural variation not anticipated by current models. (C) 2011 American Institute of Physics. [doi:10.1063/1.3597820]“
“Background: Safe and effective Japanese encephalitis (JE) vaccines are needed to protect populations living in or visiting endemic areas. A live-attenuated JE-chimeric virus vaccine (JE-CV) has been developed with a single-dose regimen.
Methods: In
an open-label, crossover study, 100 children aged 2 to 5 years with a history of 2-dose primary vaccination with mouse-brain derived inactivated JE Entinostat supplier vaccine according to the Thai Expanded Program for Immunization schedule, and 200 JE vaccination-naive 12- to 24-month-old toddlers were randomized 1: 1 to receive JE-CV, containing >= 4 log 10 plaque forming units, 1 month before or after hepatitis A control vaccine. Neutralizing antibody titers were assessed using PRNT 50 (titers expressed in inverse of dilution) before and 28 days after JE-CV, and at months 7 and 12.
Results: All 2- to 5-year-olds and 96% of 12- to 24-month-olds were seroprotected (titer >= 10) 28 days after JE-CV administration, and geometric mean titers (GMT) (95% confidence interval) in these age groups were 2634 (1928-3600) and 281 (219-362), respectively. One year later, seroprotection rates in the 2 age groups were 97% and 84% and GMTs were 454
and 62.3, respectively. Vaccine-induced antibodies neutralized a panel of wild-type JE isolates. There were no vaccine-related serious adverse events. Reactogenicity of JE-CV was comparable with that of the inactivated hepatitis A vaccine.
Conclusions: A single administration of JE-CV has a good safety profile and elicits a protective immune response in both IACS-10759 JE-naive toddlers and JE-primed young children.”
“Purpose: To investigate the optimal schemes of prostate biopsy according to prostate volume (PV), age and transrectal ultrasound (TRUS) status in Chinese men. Methods: 923 consecutive patients who underwent initial TRUS-guided systematic 12-core prostate biopsy (12PBx) were enrolled in this study. The 12PBx was obtained by overlapping of conventional sextant, lateral base, mid-gland of peripheral zone and apex. Each sample was individually marked and inked before fixation. Patients were divided into 8 subgroups on the basis of independent risk factors investigated using logistic regression model.