Results: Radiolabeling of the cyclic sulfamidate precursor 5 provides racemic [F-18]9 in high radiochemical yield (60%-70%, n=4) and high radiochemical purity

(>96%, n=4). In vitro uptake assays demonstrate that both [F-18]9a and [F-18]9b undergo tumor cell uptake through system L transport. The biodistribution studies using the single enantiomers [F-18]9a and [F-18]9b demonstrated good tumor uptake with lower uptake in most normal tissues, and [F-18]9a had higher tumor uptake than [F-18]9b. MicroPET imaging demonstrated good tumor visualization within 10 min of injection, rapid uptake of radioactivity, and tumor to brain ratios of approximately 6:1 at 60 min postinjection.

Conclusions: The novel OTX015 PET tracer, [F-18]FMePhe, is readily synthesized in good yield from a cyclic sulfamidate precursor. Biodistribution and microPET studies in the DBT model demonstrate good tumor to tissue

ratios and tumor visualization, with enantiomer [F-18]9a having higher tumor uptake. However, the brain availability of both enantiomers was lower than expected for system L substrates, suggesting the [F-18]fluorine group in the beta-position affects uptake of these compounds by system L transporters. (C) 2013 Elsevier Inc. All rights reserved.”
“Maternal psychosocial problems may affect fetal growth through maternal cortisol. This large prospective cohort study examined among 2810 women (1) the association of maternal cortisol levels with offspring birthweight and small for gestational age (SGA) risk and (2) the mediating role of maternal cortisol on the relation between maternal psychosocial problems GW4064 and fetal growth. Pregnant women in Amsterdam were approached during their first prepartum visit (+/- 13 weeks gestation). Total maternal cortisol level was determined in serum and Bumetanide maternal psychosocial indicators were collected through a questionnaire. Maternal cortisol levels were negatively related to offspring birthweight (B = -0.35; p < .001) and positively

to SGA (OR = 1.00; p =.027); after adjustment (for gestational age at birth, infant gender, ethnicity, maternal age, parity, BMI, and smoking), these effects were statistically insignificant. Post hoc analysis revealed a moderation effect by time of day: only in those women who provided a blood sample <= 09:00 h (n = 94), higher maternal cortisol levels were independently related to lower birthweights (B = -0.94; p = .025) and a higher SGA risk (OR = 1.01; p = .032). Maternal psychosocial problems were not associated with cortisol levels. In conclusion, although an independent association between maternal cortisol Levels in early pregnancy and offspring birthweight and SGA risk was not observed, exploratory post hoc analysis suggested that the association was moderated by time of day, such that the association was only present in the early morning.