CFC replacement therapy aims at reducing the number of days a PWH is at risk of spontaneous haemorrhage. In a severe this website PWH the risk of bleeding in time can be considered 100% without any replacement therapy. Now if his factor level is raised to >1%, taken as a marker of successful replacement therapy, then even at 10 IU/kg/dose given twice a week, a severe PWH. A reduces this “time at risk” by >50% (taking a t½ of 10–12 hours for FVIII). As clinical efficacy often lasts beyond levels being maintained above 1%, it

is likely that this reduction in risk time can be even greater. If this is enhanced to 10 IU/kg three times per week, this will then start reaching reduction risk times of >75%. If paradigms could be changed completely and find practical ways to administer CFC once a day then even with doses as low 5 IU/kg/day one could maintain

>1% at all time with an annual dose well below 2000 IU/kg. However, the use of such doses will also require BIBW2992 mouse that these patients be carefully monitored for their outcomes both in terms of their bleeding frequency and the development of joint and muscle disease. This may be measured by the Hemophilia Health and Joint Score (HJHS), by radiological (X-ray/ultrasonographic) assessments and collecting data on participation. This is critical for any long-term interpretation of the efficacy of this approach. So what prevents centres that have access to modest doses of CFC from adopting such an approach? The most significant perhaps is the lack of concept among health care providers because of the often stated paradigm that prophylaxis should be considered when a country has access to ∼3 IU/capita and can administer higher than 25 IU/kg three times a week. Other factors that hinder implementation of prophylaxis in developing countries are lack of awareness among PWH, irregularity of access to CFC, local distribution and issues related to individual patients. However,

all these are surmountable problems and should be addressed if we are to reduce the burden of bleeding related complications of haemophilia within the quantity of CFC that is already available. When the standard of care cannot MCE公司 be achieved, young PWH experience severe musculoskeletal complications, resulting in altered body functions, limited activities, and participation in society. Especially in the young age participation takes place in school activities, determining their possibilities in society at a later stage. Therefore, rehabilitation remains an inexpensive and efficient treatment option in order to minimize the detrimental effects of joint and muscle bleedings and to increase the functional independence and quality of life for PWH.