parvum and U. urealyticum and demonstration of differences in the frequency of individual species detection, studies were undertaken towards to determine pathogenicity of these microorganisms. U. urealyticum is the commonest etiologic agent of infections, including severe infections in renal transplant patients. U. urealyticum detection in patients without infections and subjectively experienced symptoms from the urogenital tract is low (1.2%) [20, 21] and significantly increases in men with NGU [20�C22] and women with PID and cervicitis [23]. Besides the fact that we did not note any specific symptoms of cervicitis in hemodialysed women, we speculate that presence of HPV in cervical epithelium may support colonization with U. urealyticum. M. genitalium DNA detection in our study was 3% in control group and 9.

4% in hemodialysed women. Although it is a high percentage, our study was limited by small number of patients in study group. Many studies confirm low percentage of M. genitalium in healthy women without symptoms: 4.5% of positive cases were described by English authors [24]. In Denmark, among 731 men and 921 women aged 21�C23 without any symptoms in the urogenital tract, M. genitalium DNA was demonstrated in 2.3% women and in 1.1% men [25]. M. genitalium is clearly defined as an etiologic agent of STI. Clinical indications for next studies of this species are urethritis, epididymitis, and prostatitis in men and cervicitis, urethritis, and PID in women [26]. More than 9% of positive M. genitalium cases among studied hemodialysed women suggest importance of this microorganism as an etiological agent of possible complications.

Fairley et al. demonstrated 20% HPV positive cases in hemodialysed women versus 4.5% cases in control group [27]. This suggests that hemodialysed women belong to higher risk group for abnormal Pap and/or development of cervical cancer. In our study we demonstrated equal detection of HPV in hemodialysed and healthy women (25% versus 23%). However, different primers for HPV detection were used by Fairley et al. and in our study (Amplicor detects 13 different genotypes of HPV). We demonstrated cooccurrence of HPV and urogenital mycoplasmas in 75% of hemodialysed women, suggesting importance of this cooccurrence and necessity of further studies.

We summarize that because of demonstrated significant differences in occurrence of urogenital mycoplasmas in hemodialysed Batimastat women and controls these microorganisms can cause future complications especially in patients preparing for renal transplantation and receiving immunosuppressive therapy.5. ConclusionSignificantly higher incidence of urogenital mycoplasmas and cooccurrence with HPV was demonstrated in hemodialysed women. The need to take into account these microorganisms in routine diagnostics, especially for hemodialysed patient, was demonstrated.