5 +/- 9.4 years, 53% male vs. 14.9 +/- 1.8 years, 63% male). A cardiothoracic surgical procedure occurred in 81.4% of admissions. Adult admissions weighed less than pediatric admissions (72.8 +/- 22.4 kg vs. 85.6 +/- 14.9 kg, P < .01) but hospital length of stay was similar. (Adult 6 days [range 1-216 days]; pediatric 5 days [Range 2-123 days], P = .52.)\n\nA total of 112 prescribing errors were identified and they occurred less often in adults (42.4% of admissions vs. 66.7% of admissions, P = .02). Adults had a lower mean number of errors (0.7 errors per adult admission vs. 1.7 errors per pediatric admission,

P < .01). Prescribing errors occurred most commonly with antimicrobials (n = 27). Underdosing was the most common category of prescribing error. Most prescribing errors were determined

to have not caused harm to the patient.\n\nConclusions\n\nPrescribing AZD6738 PI3K/Akt/mTOR inhibitor errors occur frequently in adult patients admitted to a pediatric CVICU but occur more often in pediatric patients of adult weight.”
“Mice, similarly to some other rodent species, communicate with specialized sounds in the ultrasonic range called ultrasonic vocalizations (USV). Evaluation of this behavioral activity GSK1210151A research buy enables estimation of the social interactions in animal models of autistic spectrum disorders (ASD). Because transgenic mouse models are generated, in most cases, on the mixed 129SV/C57BL6 genetic background, we were interested if parameters that

characterize USV differ between these two mouse strains. In addition, we wanted to compare these strains with the BALB/c line. In order to analyze USV, we applied the standard isolation test to newborn animals and compared standard parameters. Obtained results indicate clear differences between the 129SV and C57BL6 strains in respect to all analyzed USV parameters. Both strains behave also differently when compared with the BALB/c strain. For this reason in experiments utilizing transgenic animals, contribution of various genetic backgrounds has to be carefully considered.”
“Bioprocess model structures Tubastatin A that require nonlinear parameter estimation, thus initialization values. are often subject to poor identification performances because of the uncertainty on those initialization values. Under some conditions on the model structure, it is possible to partially circumvent this problem by an appropriate decoupling of the linear part of the model from the nonlinear part of it. This article provides a procedure to be followed when these structural conditions are not satisfied. An original method for decoupling two sets Of parameters, namely, kinetic parameters from maximum growth, production, decay rates, and yield coefficients, is presented. It exhibits the advantage of requiring only initialization of the first subset of parameters.