, 1994) and applied to the MEG data. The anatomically normalized MEG data were filtered with a Gaussian kernel of 20 mm (full-width at half-maximum) in the x,

y, and z axes (voxel dimension was 5.0×5.0×5.0 mm). The decreased oscillatory powers, that is, ERDs, for β-band (13–25 Hz), α-band (8–13 Hz), θ-band (4–8 Hz), δ-band (1–4 Hz), and γ-band (25–50 Hz) within the time window of 0–1000 ms (every 100 ms) in the suppression sessions relative to the motivation sessions were measured on a region-of-interest basis in order to obtain the neural activation pattern related to the suppression of appetitive motivation. Baseline corrections were conducted with the time window of −500 ms to 0 ms. The resulting set of voxel values for each comparison constituted a SPM of the t statistics (SPMt). The SPMt was transformed to the unit of normal distribution (SPMZ). The threshold for the SPMZ of individual learn more analyses was set at P<0.05 (corrected for multiple comparisons). The weighted sum of the parameters estimated in the individual analyses consisted of “contrast” images, which were used for the group analyses ( Friston et al., 1999). Individual data were summarized and incorporated into a random-effect

model so that inferences could be made at a population level ( Friston et al., 1999). SPMt and SPMZ for the contrast images were created as described above. Significant signal changes for each contrast were assessed by means of t statistics on a voxel-by-voxel basis ( Friston et al., 1999). The threshold for the SPMZ of Pirfenidone group analyses was set at P<0.05 (corrected for multiple comparisons). Anatomical localizations of significant voxels within

clusters were done using the Talairach Demon software ( Lancaster et al., 2000). Anatomic MRI was performed using a Philips Achieva 3.0TX (Royal Philips Electronics, Eindhoven, the Netherlands) for all participants to permit registration of magnetic source locations with their respective anatomic locations. Before MRI scanning, five adhesive markers (Medtronic Surgical Navigation Technologies Inc., Broomfield, CO) were attached to the skin of each participant’s head (the first and second markers Tyrosine-protein kinase BLK were located 10 mm in front of the left tragus and right tragus, the third at 35 mm above the nasion, and the fourth and fifth at 40 mm right and left of the third one). MEG data were superimposed on MRI scans using information obtained from these markers and MEG localization coils. Data are expressed as mean±SD unless otherwise stated. Pearson’s correlation analyses were used to evaluate the relationships between the MEG and subjective variables. All P values were two-tailed, and values less than 0.05 were considered statistically significant. Statistical analyses were performed using the SPSS 18.0 software package (SPSS, Chicago, IL).