We aimed to investigate an alternative subdivision of FGD, taking into account gastric sensorimotor function, anxiety & depression and ‘somatization’, besides gastroduodenal symptoms. Methods Gastroduodenal symptom data were available for 857 consecutive FGD patients (Rome II criteria). In a subsample (n = 259), additional data were obtained on gastric sensitivity, anxiety, depression and ‘somatization’. Two separate cluster analyses were performed. In analysis 1, clustering was based on individual gastroduodenal symptom scores. In analysis 2, gastric sensitivity,
anxiety & depression and ‘somatization’, besides total gastroduodenal symptoms score, were used for clustering. Key Results Analysis 1 identified four clusters, largely supporting the Rome III classification, with
early satiation, I-BET-762 in vitro pain and nausea/vomiting clusters, besides a limited severity cluster (R(2) = 0.32). Analysis 2 suggested a five-cluster solution (R(2) = 0.48). Anxiety, depression and ‘somatization’ GSI-IX in vitro were the most important variables separating the clusters. ‘Primary somatization’ (with low psychiatric symptom levels) as well as ‘secondary somatization’ (with high anxiety & depression scores) subgroups were identified, besides three other subgroups characterized by psychiatric/gastroduodenal symptoms, mild anxiety symptoms and limited overall severity, respectively. Conclusions & Inferences We propose an alternative to the current subgrouping in FGD that is exclusively based on gastroduodenal symptoms. This may have consequences
for future classification of FGD, as well as broader relevance towards the debate on subgrouping click here ‘functional somatic syndromes’.”
“Objective: This study aimed to examine the extent to which illness perceptions and coping strategies among women diagnosed with breast cancer explain psychological distress at diagnosis and at 6 months post diagnosis relative to demographic and illness-related variables.\n\nMethods: Women were recruited to the study shortly after diagnosis. A total of 90 women completed study materials (Illness Perception Questionnaire-Revised, the Cancer Coping Questionnaire and the Hospital Anxiety and Depression Scale) at time 1. The same questionnaires were sent approximately 6 months later to those who had consented at time 1, and completed questionnaires were returned by 72 women.\n\nResults: Cluster analysis was used to identify groups of respondents who reported a similar profile of illness perception scores. Regression analysis demonstrated that one of these clusters was more likely to experience psychological distress than the other both at diagnosis and at 6 months post diagnosis.