The significance of linkage disequilibrium was tested by a parametric method [58] as implemented in LIAN 3.5. Acknowledgements and funding We are grateful to Lourdes Martínez-Aguilar for technical assistance in the isolation of click here Mexican BCC strains and Claudio Ferrelli for technical informatics assistance. We also thank Alessandra Pasquo, Silvia Dalmastri, and Ryan Robert (UCC Biomerit Research Centre) for critical revision of the manuscript. We

are also very grateful to the editor and the two anonymous reviewers for their suggestions in improving the manuscript. This research was partially funded by grant DGAPA-UNAM IN229005 and grant N.29 of the Italian Ministry of Foreign Affairs (Italian-Mexican Scientific Cooperation 2003-2005). We dedicate the present study to the memory of the late Dr Jesus Caballero-Mellado (Centro de Ciencias Genómicas, Universidad Nacional Autónoma de México, Cuernavaca, Morelos, Mexico). He greatly contributed to the design of this study as well as he was involved in the discussion of data and manuscript preparation. With Jesus’s death, we lost an excellent scientist, a loyal and generous friend, a marvelous speaker, a charming person of the highest

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