The combined effect of the LPL gene polymorphisms and diabetes may contribute to the development of a subgroup of ischemic stroke.”
“Objective: To assess the long-term ototoxicity effect of platinum chemotherapy in a series of pediatric patients.
Design: A prospective cohort study.
Methods: Patients who received platinum chemotherapy were identified through review of the pharmacy records from 2000 to 2005. Audiograms pre- and post-treatment with cisplatin were noted. The patients were brought
back long after treatment for a repeat audiogram and a questionnaire to assess the impact of ototoxicity on their quality of life.
Results: Forty-nine patients received platinum MAPK Inhibitor Library screening chemotherapy. Patients’ exclusion: two had no pre-chemo audiograms, one had retinoblastoma with congenital hearing loss, three were lost to Selleck GSK621 follow up, five deceased, and seven refused participation. The total number of patients included was 31 with long-term follow up total of 21 patients. The
follow up period ranged from 1.5 to 6.6 years (median of 3.4 years). Fourty-two percent (13/31) of the patients suffered from otoxicity (3 mild, 3 moderate, 7 severe-profound). Thirty-three (7/21) of audiograms worsened on long-term follow up. Questionnaire revealed 70% subjective hearing loss with 40% requiring hearing aids.
Conclusion: Ototoxicity after platinum chemotherapy can present or worsen years after completion of therapy. Therefore, we recommend long-term follow up. Crown Copyright (C) 2010 Published by Elsevier Ireland Ltd. All rights reserved.”
“Background and purpose: Recently, orthostatic myoclonus (OM) has been suggested as a cause of gait impairment and unsteadiness in neurodegenerative diseases. The aim of this study was to investigate the frequency of orthostatic myoclonus, its clinical characteristics and the underlying associated neurological disorders.
Methods: A retrospective analysis of clinical data and electromyogram surface recordings
from subjects with unexplained unsteadiness/gait impairment was performed. Diagnosis of OM was made when a pattern of non-rhythmic bursts was observed (duration range 20-100 ms; bursts per second <= 16).
Results: Among 93 subjects studied, OM was the most frequent disorder (n = 16; 17.2%), followed AZD6244 MAPK inhibitor by orthostatic tremor (13.9%) and low frequency tremors during orthostatism (12.9%). All patients with OM complained about unsteadiness during orthostatism and/or during gait. Leg jerking was only observed by visual inspection during orthostatism in four subjects and two also presented falls. Eleven out of 16 patients (68.7%) with OM had an associated neurodegenerative disease, such as multiple system atrophy (n = 3) Parkinson’s disease (n = 2), Alzheimer’s disease (n = 2), mild cognitive impairment (n = 2) and normal pressure hydrocephalus (n = 2).