The severity was assessed based on apnea hypoapneaindex(AHI). All CKD patients attending the outpatient department from January 2012 to July 2013 were assessed using Cockroft and Gault formula and assigned in either of the two groups based on the GFR. Results: A total of 647 patients were screened BMS-354825 manufacturer and 302(46.67%) patients were in stage 2,3 and 4 of CKD. 87(28%) among the 302 were at high risk for berlin questionnaire). 37(42.5%) patients among the 87 patients were excluded based on the exclusion criteria. 50 patients underwent split night

sleep study, polysomnography testing. The prevalence of obstructive sleep apnea was found to be 28% after screening the population with Berlin questionnaire. The incidence of obstructive sleep apnea was found to be 25.4% in the Berlin questionnaire positive GSI-IX cell line after polysomnography. The Mann Whitney U-test statistics was applied and astatistical significance (p < 0.05) between Early and Late CKD with respect to AHI and ODI was observed. An improvement in the Late CKD is observed and the Z values for AHI and ODI were 4.273 and 2.307respectively which was statistically significant. Conclusion: This is the first study in South Indian population to assess the prevalence of obstructive sleep apnea

in non dialysis chronic kidney patients. This study indicates the necessary to screen the Non dialysis CKD population for obstructive sleep apnea. Further studies with large sample sizes are needed to re-establish the increased risk of OSA associated with decline in creatinine clearance among the study Dapagliflozin population. KOBAYASHI KANA, KUBO EIJI, ARAI SHIGEYUKI, TOMIOKA SATORU, TAMURA YOSHIFURU, KURIBAYASHI EMIKO, OHTA

TATSURU, CHANG WENXIU, UCHIDA SHUNYA Department of Internal Medicine, Teikyo University School of Medicine Introduction: With the progress of renal dysfunction, ultrasonographic findings showed morphological alterations such as the increased brightness of the kidney cortex and the kidney atrophy. However, the detailed relationships between the biochemical changes and morphological changes in CKD remain to be clarified. In the present study the association of ultrasonographic findings with the degree of kidney damages was investigated by use of morphometric analyses. Methods: 1,320 CKD patients that visited Nephrology department of our hospital from June, 2010 to March, 2012 were screened. Patients with preexisting morphological diseases such as congenital anomaly, nephrectomy and polycystic kidneys, etc. were excluded. 156 CKD patients that received both the kidney ultrasonography and biochemical examination at the same occasion were enrolled for the analysis. The kidney function was evaluated by eGFR. The morphological findings examined in the study were the length of the long and short axes of the both kidneys, cortical thickness and echogenicities of the kidney cortex.