It should be noted though, that the mean age of these patients du

It should be noted though, that the mean age of these patients during the HAART-free follow-up years was lower than during the follow-up years on HAART, which could have influenced our results. Koumbarelis et al. MLN2238 showed that mortality by cerebral haemorrhage was five times higher in HIV-positive than in HIV-negative haemophilia patients (8 in 1431 vs. 8 in 7210 patient years), but in their study no data on non-fatal intracranial bleeding were available [46]. Nuss et al. reported that HIV infection was a significant

risk factor for intracranial bleeding in white haemophilia patients in the period 1993–1997 [47], but their findings could not be confirmed by Zanon et al. over the period 1987–2008 [48]. These studies, however, did not analyse traumatic and spontaneous intracranial bleeding separately. Since the introduction of HAART, the impact of HIV infection on morbidity and survival of haemophilia patients has decreased buy Alisertib significantly. Although

the occurrence of ischaemic cardiovascular events was not increased, HIV-positive haemophilia patients on HAART should be screened for cardiovascular risk factors such as hypertension, hypertriglyceridaemia and diabetes mellitus and treated accordingly. Haemophilia doctors should be aware that HIV-positive haemophilia patients on HAART (especially those using protease inhibitors) may have an increased risk of spontaneous intracranial bleeding. The authors would like to thank Astrid Pulles, Wiebe Verra and Mirthe de Boer for their help Hormones antagonist with data collection. This study was supported by an unrestricted grant from CSL Behring to DEFvdP. DEFP, KF

and EPM-B designed the study, performed data analysis and wrote the paper. GR was involved in data collection and AIMH helped with the interpretation of data. GR and AIMH both critically evaluated the manuscript. All authors approved the final version of the manuscript. The authors stated that they had no interests which might be perceived as posing a conflict or bias. “
“Summary.  Individuals with haemophilia A exhibit bleeding tendencies that are not always predicted by their factor (F)VIII level. It has been suggested that bleeding in haemophilia is due not only to defective prothrombin activation but also aberrant fibrinolysis. Thrombin activatable fibrinolysis inhibitor (TAFI) activation was measured in tissue factor (TF)-initiated blood coagulation in blood samples of 28 haemophiliacs and five controls. Reactions were quenched over time with FPRck and citrate and assayed for TAFIa and thrombin-antithrombin (TAT). The TAFIa potential (TP), TAFI activation rate and the TAFIa level at 20 min (TAFIa20 min) was extracted from the TAFI activation progress curve.

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