In the aLFD, yLFD, aHFD, and yHFD groups, bone size measures have the highest
negative correlation coefficients with size-independent mechanical measures, although significance was more difficult to achieve in the HFD groups. The next highest predictor of mechanical properties appears to be LBM, which is not surprising as bone size is highly positively correlated with LBM. FBM had a weak but negative correlation with bone size measures, and therefore appears to have little effect on mechanical properties. BMC affected mechanical properties more than aBMD, but aBMD is confounded with bone size. A size-independent measure of BMD such as volumetric BMD (vBMD) may show a stronger correlation between mineral distribution and mechanical properties. Interestingly, size-independent measures of Staurosporine nmr bone quality (strength, fracture toughness) are most affected by the size of the bone, which implies a reduced quality with
increasing quantity even in the non-obese groups. Table 1 Correlation coefficients between standardized properties in bone from (a)–(d) young and (e)–(h) BIBW2992 price adult groups Predictors a. Young LFD (n = 15) b. Young HFD (n = 15) Size-independent measures Size-dependent measures Size-independent measures Size-dependent measures (σ y , σ u , E) K c P u (σ y , σ u , E) K c P u aBMD −0.3357 0.2225 0.3055 0.0317 0.5767* 0.5089 BMC −0.2654 0.3362 0.4731
0.1793 0.4383 0.2907 (D, t, M.A.) −0.7497** 0.4931 0.1384 −0.4951 0.0037 0.214 LBM −0.4108 0.319 0.3969 −0.2584 0.0167 0.1194 FBM 0.1384 −0.2299 −0.1014 0.1582 −0.4439 −0.2404 c. Bone size in LFD—(D, t, M.A.) d. Bone size in HFD—(D, t, M.A.) LBM 0.8133*** 0.4982 FBM −0.1433 −0.4298 Predictors e. Adult LFD (n = 13a) f. Adult HFD (n = 14) Size-independent measures Size-dependent measures Size-independent measures Size-dependent measures (σ y , σ u , E) K c P u (σ y , σ u , E) K c P u aBMD 0.0808 0.2741 0.0574 −0.4976 0.2376 −0.2333 BMC −0.1709 Phosphatidylinositol diacylglycerol-lyase 0.1131 0.3577 −0.4312 −0.0746 −0.0991 (D, t, M.A.) −0.5559* 0.3858 0.7536* −0.5046 −0.3889 0.4426 LBM 0.1485 0.3775 0.5138 −0.2061 −0.1537 0.6519* FBM −0.1075 0.0715 −0.4535 −0.1394 −0.3774 −0.0796 g. Bone size in LFD—(D, t, M.A.) h. Bone size in HFD—(D, t, M.A.) LBM 0.4587 0.6377* FBM −0.1284 −0.0023 Coefficients from correlation analysis ATR inhibitor applied between standardized mechanical properties and standardized bone and physiological properties of (a), (c) young LFD group; (b), (d) young HFD group; (e), (g) adult LFD group; (f), (h) adult HFD group.