However no core species group was observed
in all studied individuals. A preliminary investigation of full genome sequences was also performed on a subset of samples in this study, revealing that similar taxonomic profiles were linked to similar metabolic profiles INCB28060 between individuals . Each of click here the two main phyla (Firmicutes and Bacteroidetes) was associated with enrichment of different metabolic pathways (transporters and carbohydrate metabolism respectively) and although the species composition differed between individuals, there was a relatively high level of functional conservation in the majority of gut microbiomes studied. Associative studies between the human gut microbiome and host factors such as inflammatory bowel disease (IBD) and weight have revealed close ties between the composition of the microorganism community and human health [4, 6, 9, 10]. Metagenomic sequencing of faecal samples from 124 European individuals was performed in order to study multiple portions of the community gene pool and link variation in community to IBD . A core gut microbiome gene pool was reported along with a proposed list of possible core species. These species were primarily from the two main phyla identified previously, and taxonomic rank
abundances were used to distinguish between IBD and non-IBD P505-15 individuals. Taxonomic differences have also been linked to obesity, especially based upon relative abundances of different phyla. Turnbaugh et al. found that obese twins had a lower proportion of Bacteroidetes than lean twins Nintedanib (BIBF 1120) . This relationship between weight and the reduction of Bacteroidetes species has also been supported by other studies [5, 10]. However, additional studies have found either no significant change in the Firmicutes: Bacteroidetes ratio [6, 11] or even an
increase in Bacteroidetes in obese individuals . The aim of our study was to investigate whether links could be made between an individual’s body mass index (BMI) and metabolic functions within the microbiome. Findings indicate that multiple components of the peptides/nickel transport system show consistent differences in abundance based upon levels of obesity within the sampled individuals. This transporter is comprised of five proteins and is likely used to transport nickel into cells and regulate its intracellular concentration , or potentially regulate the expression of cell surface molecules through selective uptake of short peptides . Despite significant differences in the abundance of complex members, the taxonomic distribution of these proteins did not differ between obese and lean individuals.