However, MD prevented neuronal

loss in the ipsilateral CA

However, MD prevented neuronal

loss in the ipsilateral CA1 area 20 days after stimulation. Our data suggest that KD can protect against epileptogenesis by preventing both after-discharge generation and propagation in kindling seizures. In addition, MD also possesses a neuroprotective function during kindling although it changes hippocampal development in early life. (C) 2011 Elsevier Ireland Ltd. All rights reserved.”
“Purpose: We assessed the correlation between urodynamic score and presence of symptoms in children with lipomyelomeningocele, and the usefulness of this measure in monitoring these children.

Materials and Methods: We prospectively evaluated 29 patients 1 month to 13 years old (mean 1.9 years) with lipomyelomeningocele from 1995 to 2010. A 4-parameter urodynamic score ranging from 0 to 17 was assigned to each patient at diagnosis and followup. Indications for surgery were presence of symptoms and signs or abnormal urodynamic score. Children were divided into 2 groups, symptomatic and asymptomatic. The latter group was further divided into operated and conservatively managed cases. Average followup was 6.7 years (range 2 to 16).

Results: The symptomatic group contained 11 children (38%) operated on at a mean age of 2.9 years. Mean followup was 6.7 years (range 2 to 12). All patients presented with an abnormal urodynamic score. Postoperative urodynamic score improved in 6 patients (55%), remained abnormal in 4 (36%) and deteriorated in 1 (9%). The asymptomatic group contained 18 patients, of whom 7 (39%) were operated learn more on at a mean age of 1.4 years. Mean followup was 10 years (range 3 to 16). Postoperative score improved in 6 patients (86%) and remained unchanged in 1 (14%). A total of 11 cases (61%) were managed conservatively, with a mean followup 4.3 years (range 2 to 7). Of these patients 3 (27%) presented with late urodynamic score deterioration at 3, 5 and 6 years of followup while remaining asymptomatic.

Conclusions: Urodynamic score is a useful tool

in monitoring children with lipomyelomeningocele because it has a good correlation with the presence of symptoms.”
“Neurodegenerative disorders, such as Alzheimer’s disease (AD), Parkinson’s disease (PD), amyotrophic lateral sclerosis (ALS), Rapamycin mouse Huntington’s disease (HD) and spinocerebellar ataxias (SCAs), present an enormous medical, social, financial and scientific problem. Recent evidence indicates that neuronal calcium (Ca(2+)) signaling is abnormal in many of these disorders. Similar, but less severe, changes in neuronal Ca(2+) signaling occur as a result of the normal aging process. The role of aberrant neuronal Ca(2+) signaling in the pathogenesis of neurodegenerative disorders is discussed here. The potential utility of Ca(2+) blockers for treatment of these disorders is also highlighted.

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