These findings suggest that screening with the stool color card could be an important,
economically feasible public health strategy for improving outcomes in BA in the U.S. Disclosures: Kathleen B. Schwarz – Consulting: Novartis, Novartis; Grant/Research Support: Bristol-Myers Squibb, Gilead, Roche/Genentech, Bristol-Myers Squibb, Vertex, Roche The following people have nothing to disclose: Douglas Mogul, Mo Zhou, Paul Intihar, Kevin Frick “
“Liver fibrosis is a complex genetic trait that is affected by multiple exogenous www.selleckchem.com/products/carfilzomib-pr-171.html (i.e., environmental) and endogenous (i.e., genetic) factors. Two recent reports in Hepatology have associated a single-nucleotide polymorphism (rs738409, I148M) in the gene encoding adiponutrin/patatin-like phospholipase
domain-containing 3 (PNPLA3) with the development of liver fibrosis and cirrhosis in hepatitis C virus (HCV)-infected patients.1, 2 In the study by Trepo et al., carriers of the PNPLA3 rs738409 GG genotype also showed a higher rate of fibrosis progression, compared to subjects carrying wild-type alleles.2 Liver transplantation (LT) for HCV liver disease is a special clinical setting in which fibrosis progression strongly determines the patient’s prognosis. Reinfection of the graft with HCV is a universal event and leads to the accelerated development of severe (i.e., ≥F3) fibrosis in 40%-50% of patients AZD4547 manufacturer with 5-10 years.3 Based on this background, see more we assessed whether the common PNPLA3 I148M polymorphism would be associated with early recurrence of severe fibrosis or other clinical parameters after LT for end-stage HCV infection. In total, 176 subjects (112 male; mean age at LT, 54.4 ± 8.1 years) were included into the study who underwent protocol biopsies for the evaluation of fibrosis progression for at least 5 years
during follow-up. When applying severe fibrosis recurrence in the graft as the main outcome parameter, the rs738409 genotype was not associated with the development of F3 fibrosis in the protocol biopsies at years 1, 3, and 5 after LT (Table 1). We also assessed whether the PNPLA3 variant would be associated with hepatocellular carcinoma (HCC), acute rejections, or diverse laboratory parameters (including alanine aminotransferase, gamma-glutamyl transferase, alkaline phosphatase, bilirubin, glucose, creatinine, and International Normalization Ratio) within the first 5 years after LT. However, we could not detect any significant associations of all of these parameters with the rs738409 genotypes or alleles. Limitations of our study were that we only genotyped the recipient, but not the donor, and that we did not directly assess histological steatosis grade in the biopsies.