90 [1.29–32.3] for UPCR 30–300 mg/g
and 17.8 [2.84–150] for UPCR > 300 mg/g, respectively, when UPCR < 30 mg/g was set as the reference. Conclusion: Proteinuria is EPZ015666 price a simple sign of coexisting systemic inflammation due to NHL and a harbinger of a poor prognosis. LIN CHENG-JUI, MA MING-CHUN, PAN CHI-FENG, CHEN HAN-HSIANG, WU CHIH-JEN Division of nephrology, Department of Internal Medicine, Mackay Memorial Hospital Introduction: Renal anemia is a common complication in patients with advanced CKD (chronic kidney disease). In vitro study showed that indoxyl sulfate (IS) will decrease erythropoietin (EPO) production. Whether this effect can be seen in vivo remain unclear. Our goal was to study the role of protein-bound uremic toxins including IS and p-cresyl sulfate (PCS) on EPO levels in a CKD cohort. Methods: Our study enrolled 113 stable CKD stage 2–5 patients in a single medical center. Serum levels of EPO, PCS, IS and biochemical data were also measured concurrently. The association of serum EPO and other independent variables were analyzed by Poisson statistical analysis. Results: Simple variable analysis showed serum EPO levels was correlated to age (r = −0.216, p < 0.05), diabetes (r = −0.223, p < 0.05), CKD stages (r = −0.239,
p < 0.05), hemoglobin (r = 0.308, p < 0.01), hematocrit (r = 0.311, p < 0.01), albumin (r = 0.212, p < 0.05), Blood urea nitrogen (r = −0.208, p < 0.05), Creatinine (r = −0.242, p < 0.05), estimated GFR (r = 0.225, p < 0.05), free IS (r = −0.201,
p < 0.05), Pexidartinib total IS (r = −0.240, p < 0.05), total PCS (r = −0.267, p < 0.01). After adjust other independent parameters, only serum albumin (B = −1.102, p = 0.01), free IS (B = −16.505, p = 0.01) and total IS (B = −0.317, p = 0.01) were significantly associated with EPO levels by multiple variable analysis. In addition, the EPO levels is lower in patients with high total IS group as compared to those with lower total IS group (p = 0.019). No significant difference was noted between patients with high and low free IS group (p = 0.170). Conclusion: Our results shows the Dichloromethane dehalogenase serum EPO levels were significantly and negatively associated with serum IS in a CKD cohort. This finding also support the idea of IS not PCS playing a role in the pathogenesis of renal anemia. MORITO TAKU1,2, ANDO MINORU1, NOKIBA HIROHIKO1, MASAKI HARA1, KEN TSUCHIYA2, NITTA KOSAKU2 1Renal Division, Department of Medicine, Tokyo Metropolitan Cancer Center, Komagome Hospital, Japan; 2Department IV of Internal Medicine, Tokyo Women’s Medical University, Japan Introduction: Microalbuminuria was reported to be a risk factor for cardiovascular event, death or development of CKD in various fields, but not yet in SCT. In this study, we have examined if new-onset microalbuminuria could be a sign of the future renal dysfunction in the setting of SCT.