050). No significant changes were noticed within the groups during the study period except for the PA group who showed a significant deterioration in Activities (Table 6). SF-36 Before the work period, the two S groups had about

the same scores in the mental health domains, whereas the PA group tended to have a lower score (Table 6). After the work period, the S+ and the PA groups showed a decrease and the S− group an increase in Vitality. Thus, significant differences were found GSK2879552 between the S− and the S+ and the PA groups, respectively. The mean difference for Vitality in the S+ group after the study period was 10.9, while no significant differences were seen in the other groups. Discussion In this study, we wanted to take a comprehensive look at the physical and psychological impact of chemical exposures hairdressers have at Compound Library screening work. The hairdressers’ nasal symptoms, mainly nasal

blockage, increased steadily during the observation period, although they improved during weekends. There was an increase in ECP in nasal lavage fluid but the nasal reactivity to persulphate did not increase. The HRQoL deteriorated in the physical as well as in the mental domains in the symptomatic hairdressers especially in Vitality (SF-36). Notably, the asymptomatic hairdressers tended to ameliorate their HRQoL during work, while the pollen allergic group was more impacted than both hairdresser groups. Methodology The participants in the S+ group were Inhibitor Library recruited from current patients at the clinic fulfilling the inclusion criteria. As very few refused to participate, we think that a selection bias is less likely. Furthermore, our groups were rather small; thus, we may miss some weak correlations. Our study period was also short. However, the risk of missing data would have increased as the loss of participants in prospective studies is a well-known problem (Kristman Oxalosuccinic acid et al. 2004). In our case, the hairdressers used to have frequent short vacancies; thus, longer observation periods with exposure was not possible. Another reason we chose a relatively short study period was to ensure compliance with journaling among

participants. The hairdressers were compared to a group of pollen allergic women. It was not practically possible to define a zero point with regard to exposure for the PA group in the same way as for the hairdressers. This affected the results in the study of the mediators and the symptoms at the start of the diary. We examined the HRQoL by choosing the SF-36 questionnaire, an extensively used generic quality of life questionnaire with acceptable discriminative but poorer evaluative properties for measuring rhinoconjunctivitis specific quality of life, and the RQLQ, which has strong discriminative and evaluative properties (Juniper et al. 2002). Specific questionnaires seem to be more sensitive to changes in HRQoL over time.