Multiple outbreaks have been reported following travel to the

Americas, but reports of pulmonary histoplasmosis in short-term immunocompetent travelers to Africa are rare. A biology student was referred to our unit with suspected pulmonary histoplasmosis following her return from a field trip in the Ugandan rainforest. The patient informed us that several of her multinational student colleagues on the same expedition had developed a similar illness. Using an alert in ProMED-mail and a questionnaire www.selleckchem.com/products/ABT-263.html forwarded to each of the symptomatic students, we accumulated data on the other cases involved in this apparent outbreak of pulmonary histoplasmosis. Thirteen of 24 students developed respiratory symptoms following the expedition. Chest X-ray appearances were often suggestive of miliary tuberculosis but in most cases a final diagnosis of histoplasmosis was made (confirmed with serology in five cases, clinically diagnosed in six, and retrospectively

suspected in two). Detailed questioning indicated that the likely source was a large hollow bat-infested tree within the rainforest. This is an unusual outbreak of histoplasmosis following short-term travel to Africa. Pulmonary histoplasmosis should always be considered in the differential diagnosis of an acute febrile respiratory illness in travelers returning from endemic find more areas or reporting activities suggesting exposure. Pulmonary histoplasmosis is caused by Histoplasma capsulatum,

a dimorphic fungus that is endemic in the Americas and parts of Asia and Africa.[1] It grows as a mold in soil enriched with bird or bat guano and human infection occurs after inhalation of the dust generated when such soil is disturbed.[2] Exposure can therefore occur during activities such as construction, renovation, demolition, excavation, and caving. Histoplasmosis has emerged as a health concern for travelers to endemic areas, particularly for those engaging Fenbendazole in recreational or occupational activities that disrupt contaminated soil. Multiple outbreaks have been reported among travelers to the Americas.[2] In contrast, there are few reports of infection occurring in immunocompetent persons after short-term travel to Africa. In this article we report an unusual outbreak of pulmonary histoplasmosis in travelers to Uganda. In September 2011, an outbreak of histoplasmosis in travelers to Uganda came to our attention when one of the cases was referred to our hospital (case 1). The patient had developed a respiratory illness following her return from a biology field trip in Uganda. This field trip undertaken by a multinational group of biology students involved researching insects and primates for 1 month in a rainforest near Fort Portal in western Uganda. Through the use of online social networks, the patient was aware that some of her colleagues on the field trip had developed a similar respiratory illness.