MPC-3100 proved to be a response rate

Another phase II study was prematurely because of toxicity Stopped t, w While evaluating the combination of cisplatin, topotecan,and cetuximab in patients with advanced squamous cell carcinoma of the building Rmutterhalses. Most patients who died this treatment experienced grade 3 or 4 myelosuppression and three of nineteen patients to treatment-related toxicity T. Erlotinib Gefitinib and are inhibitors of tyrosine kinase, MPC-3100 that block the EGF receptor. Erlotinib tested as monotherapy in patients with recurrent or metastatic endometrial cancer and proved to be a response rate of 12.5% have partial. Forty-seven percent of patients in this study had stable disease for a median duration of 3.7 months. In GOG 227D Erlotinib has been tested in patients with epidermal carcinoma With recurrence and found that ineffective in stabilization or regression of the disease. Gefitinib was no objective answer, as monotherapy in patients with advanced building Rmutterhalskrebs / recurring.
On the other side were two case reports of Tarceva as monotherapy, a small molecule EGFR inhibitor, in patients with vulvar cancer clinics interesting results. Receptor of human epidermal growth factor 2 is also a membrane-bound tyrosine kinase in the same family as the EGFR. EGFR as HER2 dimerizes upon activation mediation cell survival, proliferation and angiogenesis. about 5 23% of epithelial ovarian cancer and up to 44% of the building overexpress rmutterschleimhautkrebs HER2. HER2 gene amplification is a direct correlation between poor clinical outcome was found in malignant tumors, including many breast and ovarian cancer. Trastuzumab is a humanized monoclonal antique Body against HER2, which was effective for the treatment of many patients with HER2-positive early breast cancer.
Patients had recurrent or progressive epithelial ovarian cancer overexpression of HER2-positive 7.3% in clinical response with trastuzumab as monotherapy, but only 95 of 837 patients tested positive HER2 and only 41 patients were eligible for the study. The combination of trastuzumab with paclitaxel and carboplatin in patients with advanced ovarian cancer had a progressive completely’s Full response rate of 43%, however, only seven patients enrolled in the study, and only 22 of 321 patients tested positive showed HER2 gene amplification. Another recent study found no clinical response to trastuzumab monotherapy in patients with advanced or recurrent endometrial cancer HER2 gene amplification.
VEGF targeted agents appear in it a gr Ere effect against cancer of the building Rmutterhalses have with EGF, EGFR, HER2, and blocking agents. A Phase II trial compared head to two Ans PageSever with pazopanib, a tyrosine kinase inhibitor that Bl Cke head VEGFR and PDGFR, to lapatinib, a tyrosine kinase inhibitor of EGFR and HER2 activity t. Pazopanib is superior to lapatinib with improved progression-free survival and overall survival with minimal toxicity free t. In a multicenter phase II bevacizumab in combination with erlotinib in patients with recurrent ovarian cancer a response rate of 15% was observed, in line with the observed response rates with bevacizumab alone. A randomized phase II study of vandetanib followed by docetaxel compared vandetanib plus docetaxel was initiated by the Southwest Oncology Group.

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