Methods: 383 consecutive subjects were evaluated by means of TE and SSI. Reliable TE measurements were defined as: median value of 1 0LS measurements with a success rate>60% and an interquartile range interval<30%, values expressed in kPa. Reliable Selleck Crizotinib LS measurements by means of SSI was defined as the median value of 5 LS measurements expressed in kiloPascals (kPa).To discriminate between
various stages of fibrosis by TE we used the LS cut-offs (kPa) proposed in the most recently published meta-analysis (1): F1-6, F2-7.2, F3-9.6 and F4-14.5. Results: Our subjects were: healthy volun-teers-14.6%; patients with chronic hepatitis B -17.6%; with chronic hepatitis C – 25.8%; with coinfection (B+C or B+D) -1.6%; with non-viral chronic hepatopathies (most of them with non-alcoholic fatty liver disease)-29.2%; and with liver cirrhosis diagnosed by means of clinical, biological, ultrasound and/or endoscopic criteria-11.2%. The rate of reliable LS measurements was similar for TE and SSI: 73.9% vs. 79.9%, p=0.06. Reliable LS measurements by both elastographic methods were RG7420 manufacturer obtained in 65.2% of patients. The distribution of liver fibrosis in this cohort of patients, using TE prespecified cut-off values were: F0-40.8%, F1-14.8%, F2-19.2%, F3-12.8%, F4-12.4%. The best SSI cut-off value for predicting different stages of liver fibrosis are presented in the table. Conclusions: The best SSI cut-off values for predicting
different stages of liver fibrosis ranged between 7.1 kPa for predicting fibrosis and 11.5 kPa for predicting cirrhosis. References 1. Tsochatzis et al:J Hepatol. 2011;54:650-9. Fibrosis SSI Cut-off (kPa) AUROC Se (%) Sp (%) PPV (%) NPV (%) Accuracy (%) F≥1 >7.1 0.825 74.5 78 83.5 67.2 76 F>2 >7.8 0.859 76.8 82.6 77.9 81.5 80 F≥3 >8 0.897 92.1 75.8 55.7 96.5 79.6 F≥4 >11.5 0.914 80.6 92.7 60.9 97.1 91.2 Disclosures: The following people have nothing to disclose: Ioan Sporea, Oana Gradinaru, Simona Bota, Roxana Sirli, Alina Popescu, find more Ana Jurchis, Madalina Popescu, Mirela Danila Aim: to analyze
how many measurements are needed for the non-invasive assessment of liver fibrosis by means of SSI and which one do we need to use: the mean of median value of SSI measurements. Methods: 449 consecutive subjects were evaluated by means of TE and SSI. Reliable TE measurements were defined as: median value of 1 0 LS measurements with a success rate > 60% and an interquartile range interval< 30%, values expressed in kPa. We compared the correlation of LS assessed by SSI to TE in three situations: if the median value of 5 SSI measurements was used; if the mean value of 5 SSI measurements was used; and if the mean value of 3 SSI measurements was used. Results: We obtained reliable LS measurements by TE in 330/449 subjects (73.5%). From these subjects, in 281 cases we obtained 5 valid SSI measurements and these subjects were included in the final analysis.