Abbreviations used in this article BDI, Beck Depression Inventory; BPAD, EPZ5676 bipolar affective

disorder; ECT, electroconvulsive therapy; HAMD, Hamilton Rating Scale for Depression; HDRS, Hamilton Depression Rating Scale; IV, intravenous administration; MADRS-SI, Montgomery–Asberg Depression Rating Scale—Suicidality Item; MDD, major depressive disorder; MDE, major depressive episode; QIDS-SR, Quick Inventory of Depressive Symptomatology—Self-Report; Inhibitors,research,lifescience,medical SSF, Suicide Status Form; SSI, Scale for Suicide Ideation; TR, treatment resistant. Footnotes Funding: This research received no specific Inhibitors,research,lifescience,medical grant from any funding agency in the public, commercial, or not-for-profit sectors Conflict of interest statement: Derek Tracy has received honoraria for educational talks from Lilly UK and Roche UK. Sukhwinder Shergill has received grant support from clinical trials from GlaxoSmithKline, Roche, Abbvie and Envivo, and Inhibitors,research,lifescience,medical has served as consultant, scientific advisor and had speaking engagements for Sunovion, Roche and Dainippon Sumitomo Pharma. Contributor Information Caroline Caddy, Cognition Schizophrenia and Imaging Laboratory, Department of Psychosis Studies, the Institute of Psychiatry, King’s College London, UK. Giovanni Giaroli,

Inhibitors,research,lifescience,medical Cognition Schizophrenia and Imaging Laboratory, Department of Psychosis Studies, the Institute of Psychiatry, King’s College London, UK and North East London NHS Foundation Trust, London, UK. Thomas P. White, Cognition Schizophrenia and Imaging Laboratory, Department Inhibitors,research,lifescience,medical of Psychosis Studies,

the Institute of Psychiatry, King’s College London, UK. Sukhwinder S. Shergill, Cognition Schizophrenia and Imaging Laboratory, Department of Psychosis Studies, the Institute of Psychiatry, King’s College London, UK and South London and Maudsley NHS Foundation Trust, London, UK. Derek K. Tracy, Consultant Psychiatrist, Oxleas NHS Foundation Trust, Princess Royal University Hospital, Orpington, BR6 8NY, UK and Cognition Schizophrenia and Imaging Laboratory, Department of Psychosis Studies, the Institute of Psychiatry, King’s College London, UK.

Sir, Unoprostone Intranasal corticosteroid sprays are a mainstay treatment for allergic rhinitis and other conditions. The usual drug prescription textbooks, such as the Physicians’ Desk Reference, do not mention mania as a possible adverse event. Confronted with a bipolar patient who developed a hypomanic episode after taking mometasone furoate, we briefly reviewed the literature on the topic of mania and nonsystemic corticosteroid therapy.