One of the 5 intended doses was omitted in each of 7 patients rec

One of the 5 intended doses was omitted in each of 7 patients receiving

20 mg/m2/wk, and in 2 of the 3 patients receiving 33 mg/m2/wk, because of severe mucositis. In 2 of 4 patients receiving 50 mg/m2/wk, the last dose was omitted because of severe mucositis. None of 6 patients treated with 10 mg/m2/wk required a drug-dose modification. Radiation therapy was delivered as intended to all patients, with no breaks short of holidays. TableĀ 3 shows the commonly observed acute and late toxicities and the DLTs at each dose level. Confluent acute mucositis and pharyngitis (RTOG grade 3) occurred in most patients, including those receiving the lowest dose of gemcitabine. Hematological toxicities occurred in only one patient. High-grade (RTOG grade 3 or more)

Linsitinib solubility dmso late pharyngeal or skin toxicities occurred in 2/6 patients receiving 10 mg/m2 and both occurred frequently in the patients receiving higher drug doses: 4/8 patients in the 20 mg/m2 cohort, 2/3 in the 33-mg/m2 cohort, and 3/4 in the 50-mg/m2 cohort. DLTs were documented Tofacitinib order in 6 patients: 2/8 patients in the 20 mg/m2 cohort, 2/3 in the 33-mg/m2, and 2/4 in the 50-mg/m2 cohort. None of the patients receiving 10 mg/m2 had a DLT. The dose was escalated from 33 mg/m2/wk to 50 mg/m2/wk because the adverse events in the 33-mg/m2/wk cohort were re-graded to DLTs after the dose in the 50-mg/m2/wk cohort had already been assigned. Five of the six patients with DLTs had mucosal Morin Hydrate and/or pharyngeal DLTs consisting of persistent deep ulceration

in non-tumor-bearing areas, or pharyngeal/upper esophageal obstruction that could not be relieved by esophageal dilation and required persistent gastric tube feeding. The remaining patient had an acute hematological toxicity (low neutrophil count). Toxicity estimates using the CRM formula (which assumes a continuous dose-risk relationship) were 0.13 for 10 mg/m2, 0.19 for 20 mg/m2, 0.24 for 33 mg/m2, and 0.57 for 50 mg/m2. The MTD was defined at the level of 20 mg/m2. As expected from the small patient numbers in each cohort, the confidence intervals around these estimates are wide. The 90% confidence interval for the probability of a DLT at 20 mg/m2/wk was 0.04, 0.36. Of the 25 patients evaluable for tumor control, 15 (60%) had an initial radiological and clinical complete response, 4 had a partial response, and six had progressive disease. At a median follow-up of 30 months, locoregional control was maintained in 8 patients (32%). Distant metastases developed in 10 of 18 patients who survived at least 6 months; the most common site was the lungs. Median survival time was 20.6 months (95% CI: 14.3,41.8), and the actuarial 2-year survival rate was 41%. Survival was similar for patients receiving lower (10 or 20 mg/m2) or higher (33 or 50 mg/m2) doses of gemcitabine. Two patients in the 10-mg/m2 cohort underwent biopsies of the residual primary tumor after the first infusion of gemcitabine on day 22.

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