3 mmol/L, mitochondrial degeneration were observed; At 55.5 mmol/L, both the swelling of the endoplasmic reticulum and cytoplasm dissolved occured. Compared with 5.55 mmol/L, the expression of SCF was abundant at EPZ 6438 glucose concentrations of 25 and 33.3 mmol/L, scanty at 55.5 mmol/L. Conclusion: Some degree of hyperglucose is in favour of the expression of SCF in SMC. Excessively hyperglucose can damage the SMC ultrastructure. Key Word(s): 1. Glucose; 2. stell cell factor; 3. smoth muscle cell; Presenting Author: ZHU BINHUA Corresponding Author: ZHU BINHUA Affiliations: ying tan people’s hospital Objective: To

investigate the influence of insulin and glucose on the proliferation and the SCF expression of colonic SMC. Methods: SMCs were cultured: at different Insulin concentrations (0, 2.5, 5, 20, 40 and 80 mg/L) for different durations (0, 8, 16 and 24 hours); MTT was used to test the proliferation of SMC; SMCs were cultured at different glucose concentration (5.55, 25, 33.3, 55.5 mmol/L) for 20 days. SMC ultrastructure was observed under the electron microscope, the proliferation of SMC was tested by MTT. Results: The effect of different concentrations Akt inhibitors in clinical trials of Ins on the proliferation and the SCF expression of colonic SMC: At concentration of 5 mg/L, Ins showed

remarkable role in SMCs proliferation, the same to the concentrations of 20, 40, 80 mg/L; The SMCs incubated at glucose concentrations of 25, 33.3 mmol/L proliferated relative rapidly; At glucose concentrations of 55.5 mmol/L, the SMCs increased slowly. Conclusion: A certain concentration of Ins can promote SMC proliferation; check details Some degree of hyperglucose is in favour of SMC proliferation. Key Word(s): 1. Insulin; 2. glucose; 3. smooth muscle cells; Presenting Author: HUA YANG Additional Authors: BING-QING XIA, BO JIANG Corresponding Author: BO JIANG Affiliations: Department of Gastroenterology, Nanfang Hospital, Southern Medical University; Department

of Gastroenterology, Nanfang Hospital, Southern Medical University Objective: The diagnostic value of stool DNA (sDNA) testing for colorectal neoplasms remains controversial. To compensate for the lack of large-scale unbiased population studies, we performed a meta-analysis to evaluate the diagnostic value of sDNA testing for multiple markers of colorectal cancer (CRC) and advanced adenoma. Methods: he Pubmed, Science Direct, Biosis Review, Cochrane Library, and Embase databases were systematically searched in January 2012 without time restriction. Meta-analysis was performed using a random-effects model using sensitivity, specificity, diagnostic odds ratio (DOR), summary receiver-operating characteristic (sROC) curves, area under the curve (AUC), and 95% confidence intervals (95% CIs) as effect measures.